Yi He

TL;DR: It is shown that PX-478 prevents postradiation HIF-1 signaling and abrogates downstream stromal adaptation in C6 and HN5 reporter xenografts as measured by serial ultrasound, vascular magnetic resonance imaging, and hypoxia response element–specific micro–positron emission tomography imaging.

TL;DR: PX-478 is a mechanistically appealing and potentially clinically relevant enhancer of pancreatic cancer radiosensitivity, inhibiting tumor and stromal HIF-1 proangiogenic signaling and reducing the innate radiation resistance of hypoxic tumor cells.

TL;DR: The results illustrate that tumor radioresistance is mediated by a capacity to compensate for stromal vascular disruption through HIF-1–dependent proangiogenic signaling and that clinically relevant vascular imaging techniques can spatially define mechanisms associated with tumor irradiation.

TL;DR: An overview of latest progress in the field of cyclodextrin-based multifunctional co-delivery systems for cancer synergistic therapy is provided.

TL;DR: In this article , the authors modified the classical MMTV-PyMT breast carcinoma model to trace the fate of mammary-derived carcinoma cells, and they showed that within the lung, when the metastatic breast cancer cells are conditionally depleted, transformed lung epithelial cells generate new metastases.