Yi Li

TL;DR: Using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, two loci contributing to risk of MDD on chromosome 10 are identified: one near the SIRT1 gene and the other in an intron of the LHPP gene.

TL;DR: It is demonstrated that changes in the amount of mtDNA and telomere length are consequences of stress and entering a depressed state and have important implications for understanding how stress causes the disease.

TL;DR: CSA is strongly associated with recurrent MD and this association increases with greater severity of CSA, and among the depressed women, those with CSA had an earlier age of onset, longer depressive episodes.

TL;DR: Significantly more episodes of MDD occur among those with lower educational attainment (rather than longer episodes of disease), consistent with the hypothesis that the lower socioeconomic position increases the likelihood of developing MDD.

TL;DR: The present findings indicate that specific factors act to increase the likelihood of suicide in MD, and may help improve the clinical assessment of suicide risk in depressed patients, especially for women.