Y
Yi Zhao
Researcher at Singapore General Hospital
Publications - 123
Citations - 4951
Yi Zhao is an academic researcher from Singapore General Hospital. The author has contributed to research in topics: LRRK2 & Population. The author has an hindex of 29, co-authored 113 publications receiving 4274 citations. Previous affiliations of Yi Zhao include Institute of High Performance Computing Singapore & Cornell University.
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Journal ArticleDOI
Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
Ellen Sidransky,Mike A. Nalls,Jan O. Aasly,Judith Aharon-Peretz,Grazia Annesi,Egberto Reis Barbosa,Anat Bar-Shira,Daniela Berg,Jose Bras,Jose Bras,Alexis Brice,Alexis Brice,Chiung-Mei Chen,Lorraine N. Clark,Christel Condroyer,Elvira Valeria De Marco,Alexandra Durr,Alexandra Durr,Michael J. Eblan,Stanley Fahn,Matthew J. Farrer,Hon-Chung Fung,Ziv Gan-Or,Thomas Gasser,Ruth Gershoni-Baruch,Ruth Gershoni-Baruch,Nir Giladi,Nir Giladi,Alida Griffith,Tanya Gurevich,Tanya Gurevich,Cristina Januário,Peter Kropp,Anthony E. Lang,Guey Jen Lee-Chen,Suzanne Lesage,Karen Marder,Ignacio F. Mata,Anat Mirelman,Jun Mitsui,Ikuko Mizuta,Giuseppe Nicoletti,Giuseppe Nicoletti,Catarina R. Oliveira,Ruth Ottman,Avi Orr-Urtreger,Lygia da Veiga Pereira,Aldo Quattrone,Aldo Quattrone,Ekaterina Rogaeva,Arndt Rolfs,Hanna Rosenbaum,Roberto Rozenberg,Ali Samii,Ali Samii,Ali Samii,Ted Samaddar,Claudia Schulte,Manu Sharma,Manu Sharma,Andrew B. Singleton,Andrew B. Singleton,Mariana Spitz,Mariana Spitz,Eng-King Tan,Eng-King Tan,Nahid Tayebi,Tatsushi Toda,André R. Troiano,Shoji Tsuji,Matthias Wittstock,Tyra G. Wolfsberg,Yih-Ru Wu,Cyrus P. Zabetian,Yi Zhao,Shira G. Ziegler +75 more
TL;DR: Data collected demonstrate that there is a strong association between GBA mutations and Parkinson's disease, and those with a GBA mutation presented earlier with the disease, were more likely to have affected relatives, and were morelikely to have atypical clinical manifestations.
Journal ArticleDOI
Analysis of Lrrk2 R1628P as a Risk Factor for Parkinson's Disease
Owen A. Ross,Yih-Ru Wu,Mei-Ching Lee,Manabu Funayama,Meng-Ling Chen,Alexandra I. Soto,Ignacio F. Mata,Guey Jen Lee-Chen,Chiung Mei Chen,Michelle Tang,Yi Zhao,Nobutaka Hattori,Matthew J. Farrer,Eng-King Tan,Eng-King Tan,Ruey-Meei Wu +15 more
TL;DR: In this article, the authors show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations.
Journal ArticleDOI
The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence.
Eng-King Tan,Eng-King Tan,Yi Zhao,Lisa Skipper,M. G. Tan,A. Di Fonzo,L. Sun,Stephanie Fook-Chong,S. Tang,E. Chua,Yih Yuen,Louis C. Tan,R. Pavanni,R. Pavanni,Meng-Cheong Wong,Meng-Cheong Wong,Prasanna R. Kolatkar,Chin Song Lu,Vincenzo Bonifati,Jianjun Liu +19 more
TL;DR: This study lends support to the contention that the Gly2385Arg is a common risk factor for PD in the Chinese population and suggests that it is biologically relevant and it might act through pro-apoptotic mechanisms.
Journal ArticleDOI
Large-scale replication and heterogeneity in Parkinson disease genetic loci
Manu Sharma,John P. A. Ioannidis,Jan O. Aasly,Grazia Annesi,Alexis Brice,Christine Van Broeckhoven,Lars Bertram,Maria Bozi,David Crosiers,Carl E Clarke,Maurizio F. Facheris,Matthew J. Farrer,Gaëtan Garraux,Suzana Gispert,Georg Auburger,Carles Vilariño-Güell,Georgios M. Hadjigeorgiou,Andrew A. Hicks,Nobutaka Hattori,Beom S. Jeon,Suzanne Lesage,Christina M. Lill,Juei-Jueng Lin,Timothy Lynch,Peter Lichtner,Anthony E. Lang,Vincent Mok,Barbara Jasinska-Myga,George D. Mellick,Karen E. Morrison,Grzegorz Opala,Peter P. Pramstaller,Irene Pichler,Sung Sup Park,Aldo Quattrone,Ekaterina Rogaeva,Owen A. Ross,Leonidas Stefanis,Joanne D. Stockton,Wataru Satake,Peter A. Silburn,Jessie Theuns,Jessie Theuns,Eng-King Tan,Tatsushi Toda,Hiroyuki Tomiyama,Ryan J. Uitti,Karin Wirdefeldt,Zbigniew K. Wszolek,Georgia Xiromerisiou,Kuo Chu Yueh,Yi Zhao,Thomas Gasser,Demetrius M. Maraganore,Rejko Krüger +54 more
TL;DR: This study allows insight into the distribution of newly identified genetic factors contributing to PD and shows that large-scale evaluation in diverse populations is important to understand the role of population-specific heterogeneity.
Journal ArticleDOI
Multiple LRRK2 variants modulate risk of Parkinson disease: a chinese multicenter study
Eng-King Tan,Rong Peng,Yik Ying Teo,Louis C.S. Tan,Dario C. Angeles,Patrick Ho,Meng Ling Chen,Chin-Hsien Lin,Xue Ye Mao,Xue Li Chang,Kumar M. Prakash,Jianjun Liu,Wing Lok Au,Weidong Le,Joseph Jankovic,Jean Marc Burgunder,Jean Marc Burgunder,Yi Zhao,Ruey-Meei Wu +18 more
TL;DR: It is provided the first evidence that multiple LRRK2 variants exert an individual effect and together modulate the risk of PD among Chinese patients.