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Yifan Cheng

Researcher at University of California, San Francisco

Publications -  214
Citations -  28269

Yifan Cheng is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Chemistry & Transient receptor potential channel. The author has an hindex of 63, co-authored 190 publications receiving 22203 citations. Previous affiliations of Yifan Cheng include Wuhan University & Chinese Academy of Sciences.

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Journal ArticleDOI

MotionCor2: Anisotropic Correction of Beam-Induced Motion for Improved Cryo-Electron Microscopy

Shawn Q. Zheng, +5 more
- 01 Apr 2017 - 
TL;DR: MotionCor2 software corrects for beam-induced sample motion, improving the resolution of cryo-EM reconstructions.
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Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

Xueming Li, +10 more
- 01 Jun 2013 - 
TL;DR: This approach determined a 3.3-Å-resolution structure of an ∼700-kDa protein with D7 symmetry, the Thermoplasma acidophilum 20S proteasome, showing clear side-chain density and greatly enhances image quality and data acquisition efficiency.
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Structure of the TRPV1 ion channel determined by electron cryo-microscopy

Maofu Liao, +3 more
- 05 Dec 2013 - 
TL;DR: In this article, a high-resolution electron cryo-microscopy structure of the rat transient receptor potential (TRP) channel in its closed state is presented; the overall structure of this ion channel is found to share some common features with voltage-gated ion channels, although several unique, TRP-specific features are also characterized.
Journal ArticleDOI

TRPV1 structures in distinct conformations reveal activation mechanisms

Erhu Cao, +3 more
- 05 Dec 2013 - 
TL;DR: Pharmacological probes are exploited to determine structures of two activated states of the capsaicin receptor, TRPV1, and allosteric coupling between upper and lower gates may account for rich physiological modulation exhibited by TRpV1 and other TRP channels.
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EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy

Benjamin A Barad, +7 more
- 01 Oct 2015 - 
TL;DR: EMRinger, a tool that assesses the precise fitting of an atomic model into the map during refinement and shows how radiation damage alters scattering from negatively charged amino acids is reported.