Yifang Hu

TL;DR: The philosophy and design of the limma package is reviewed, summarizing both new and historical features, with an emphasis on recent enhancements and features that have not been previously described.

TL;DR: ELDA is a software application for limiting dilution analysis (LDA), with particular attention to the needs of stem cell assays, which is the first limiting dilutions analysis software to provide meaningful confidence intervals for all LDA data sets, including those with 0% or 100% responses.

TL;DR: Comparing the gene expression profiles of Trm cells isolated from the brain with those of circulating memory T cellsisolated from the spleen after an acute virus infection indicates that Trm Cells are a distinct memory T cell population disconnected from the circulatingMemory T cell pool and display a unique molecular signature that likely results in optimal survival and function within their local environment.

TL;DR: It is shown that Id2 is broadly expressed in all cDC subsets with the highest expression in CD103+ and CD8α+ lineages and that Irf‐8 and Batf3 regulate distinct stages in DC differentiation during the development of cDCs.

TL;DR: It is shown that mice with loss of function mutations in PRC2 components display enhanced HSC/progenitor population activity, whereas mutations that disrupt PRC1 or pleiohomeotic repressive complex are associated with HSC or progenitor cell defects.