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Yiguang Chen

Bio: Yiguang Chen is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Carbon-13 NMR & Fusarium oxysporum. The author has an hindex of 7, co-authored 8 publications receiving 270 citations.

Papers
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Journal ArticleDOI
TL;DR: Three metabolites named phomopsin A, B and C, together with two known compounds cytosporone B (4) and C (5), were isolated from the mangrove endophytic fungus, Phomopsis sp.

137 citations

Journal ArticleDOI
TL;DR: Three metabolites named phomopsin A, B and C, together with two known compounds cytosporone B (4) and C (5), were isolated from the mangrove endophytic fungus, Phomopsis sp.
Abstract: Three metabolites named phomopsin A (1), B (2) and C (3), together with two known compounds cytosporone B (4) and C (5), were isolated from the mangrove endophytic fungus, Phomopsis sp. ZSU-H76 obtained from the South China Sea. Their structures were elucidated by spectroscopic methods, mainly by 1D and 2D NMR spectroscopic techniques. The medium-sized cyclic phenol ether based on 1 or 2 is rare in natural products. In bioassays, compounds 1, 2, and 3 had no significant antibiotic activities, but compounds 4 and 5 inhibited two fungi Candida albicans and Fusarium oxysporum with an MIC ranging from 32 to 64 microg/ml.

60 citations

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TL;DR: In this paper, the first report on xanthone derivatives isolated as secondary metabolites from mangrove endophytic fungus Phoma sp. SK3RW1M was published.
Abstract: A new lactone, 1,8-dihydroxy-10-methoxy-3-methyldibenzo[b,e]oxepine-6,11-dione (1), and two new xanthones, 1-hydroxy-8-(hydroxymethyl)-6-methoxy-3-methyl-9H-xanthen-9-one (2) and 1-hydroxy-8-(hydroxymethyl)-3-methoxy-6-methyl-9H-xanthen-9-one (3), were isolated from a mangrove endophytic fungus Phoma sp. SK3RW1M collected from the South China Sea. This is the first report on xanthone derivatives isolated as secondary metabolites from Phoma species. Their structures were elucidated by spectroscopic methods, mainly 1D- and 2D-NMR techniques, and the structure of compound 2 was confirmed by X-ray crystallography. Cytotoxicity assays showed that compounds 1–3 were inactive against KB and KBv200 cells.

32 citations

Journal ArticleDOI
TL;DR: In this paper, a new isochroman, (3R,4S)-3,4-dihydro-4,5,8-trihydroxy-3-methylisocoumarin (1), and two known compounds were isolated from the marine fungus Phomopsis sp. (No. ZH-111).
Abstract: A new isochroman, (3R,4S)-3,4-dihydro-4,5,8-trihydroxy-3-methylisocoumarin (1), and two known compounds were isolated from the marine fungus Phomopsis sp. (No. ZH-111). Their structures were determined by spectroscopic methods, mainly 1D and 2D NMR. Preliminary pharmacological test revealed that compound 1 and exumolide A (3) can accelerate the growth of subintestinal vessel plexus (SIV) branches markedly and compound 2 can inhibit the growth of subintestinal vessel plexus (SIV) branches.

23 citations

Journal ArticleDOI
TL;DR: Preliminary pharmacological test showed that the new anthraquinone derivatives exhibited low cytotoxic activity towards KB, KBv200, and MCF‐7 cell lines.
Abstract: The structure elucidations and complete (1)H and (13)C NMR assignments are reported for three new anthraquinone derivatives: Fusaquinon A (1), B (2), and C (3) isolated from the fermentation medium of the marine fungus Fusarium sp. (No. ZH-210). HREIMS, Fourier transform infrared absorption spectrometry (FT-IR), NMR experiments including gCOSY, gHMQC, gHMBC, and NOESY were used for the determination of the structures and NMR spectral assignments. Preliminary pharmacological test showed that they exhibited low cytotoxic activity towards KB, KBv200, and MCF-7 cell lines.

19 citations


Cited by
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Journal ArticleDOI
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.

4,649 citations

Journal ArticleDOI
TL;DR: An overview of new natural products from marine-derived fungi and their biological activities, focusing on the period from 2006 until mid-2010, with a considerable number of which display promising biological and pharmacological properties.

555 citations

Journal ArticleDOI
01 Jan 2012
TL;DR: This review covers the literature published in 2010 for marine natural products, with 895 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
Abstract: Covering: 2010. Previous review: Nat. Prod. Rep., 2011, 28, 196. This review covers the literature published in 2010 for marine natural products, with 895 citations (590 for the period January to December 2010) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1003 for 2010), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

413 citations

Journal ArticleDOI
TL;DR: In this review, many well-studied areas are presented and examples will be given to discuss the structure of compounds isolated from endophytes extracts with antimicrobial activities and show the wide variety of approaches taken within the field.

390 citations

Journal ArticleDOI
TL;DR: In this article, the authors describe the xanthones as "privileged structures" and describe methods for the construction of the (polysubstituted) unsaturated xanthone core.
Abstract: Many fungi, lichens, and bacteria produce xanthones (derivatives of 9H-xanthen-9-one, “xanthone” from the Greek “xanthos”, for “yellow”) as secondary metabolites. Xanthones are typically polysubstituted and occur as either fully aromatized, dihydro-, tetrahydro-, or, more rarely, hexahydro-derivatives. This family of compounds appeals to medicinal chemists because of their pronounced biological activity within a notably broad spectrum of disease states, a result of their interaction with a correspondingly diverse range of target biomolecules. This has led to the description of xanthones as “privileged structures”.(1) Historically, the total synthesis of the natural products has mostly been limited to fully aromatized targets. Syntheses of the more challenging partially saturated xanthones have less frequently been reported, although the development in recent times of novel and reliable methods for the construction of the (polysubstituted) unsaturated xanthone core holds promise for future endeavors. In particular, the fascinating structural and biological properties of xanthone dimers and heterodimers may excite the synthetic or natural product chemist.

310 citations