Y
Yihan Li
Researcher at Wellcome Trust Centre for Human Genetics
Publications - 36
Citations - 2997
Yihan Li is an academic researcher from Wellcome Trust Centre for Human Genetics. The author has contributed to research in topics: Major depressive disorder & Genome-wide association study. The author has an hindex of 20, co-authored 35 publications receiving 2258 citations. Previous affiliations of Yihan Li include Wellcome Trust.
Papers
More filters
Journal ArticleDOI
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Naomi R. Wray,Stephan Ripke,Stephan Ripke,Stephan Ripke,Manuel Mattheisen,Maciej Trzaskowski,Enda M. Byrne,Abdel Abdellaoui,Mark Adams,Esben Agerbo,Esben Agerbo,Tracy Air,Till M.F. Andlauer,Silviu Alin Bacanu,Marie Bækvad-Hansen,Marie Bækvad-Hansen,Aartjan F.T. Beekman,Tim B. Bigdeli,Elisabeth B. Binder,Elisabeth B. Binder,Douglas Blackwood,Julien Bryois,Henriette N. Buttenschøn,Henriette N. Buttenschøn,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,Na Cai,Na Cai,Enrique Castelao,Jane H. Christensen,Jane H. Christensen,Toni-Kim Clarke,Jonathan I.R. Coleman,Lucía Colodro-Conde,Baptiste Couvy-Duchesne,Nicholas John Craddock,Gregory E. Crawford,Cheynna A. Crowley,Hassan S. Dashti,Hassan S. Dashti,Gail Davies,Ian J. Deary,Franziska Degenhardt,Eske M. Derks,Nese Direk,Nese Direk,Conor V. Dolan,Erin C. Dunn,Erin C. Dunn,Thalia C. Eley,Nicholas Eriksson,Valentina Escott-Price,Farnush Hassan Farhadi Kiadeh,Hilary K. Finucane,Hilary K. Finucane,Andreas J. Forstner,Josef Frank,Helena Gaspar,Michael Gill,Paola Giusti-Rodríguez,Fernando S. Goes,Scott D. Gordon,Jakob Grove,Lynsey S. Hall,Lynsey S. Hall,Eilis Hannon,Christine Søholm Hansen,Christine Søholm Hansen,Thomas Hansen,Thomas Hansen,Stefan Herms,Stefan Herms,Ian B. Hickie,Per Hoffmann,Per Hoffmann,Georg Homuth,Carsten Horn,Jouke-Jan Hottenga,David M. Hougaard,David M. Hougaard,Ming Hu,Craig L. Hyde,Marcus Ising,Rick Jansen,Fulai Jin,Eric Jorgenson,James A. Knowles,Isaac S. Kohane,Isaac S. Kohane,Isaac S. Kohane,Julia Kraft,Warren W. Kretzschmar,Jesper Krogh,Zoltán Kutalik,Zoltán Kutalik,Jacqueline M. Lane,Jacqueline M. Lane,Yihan Li,Yun Li,Penelope A. Lind,Xiaoxiao Liu,Leina Lu,Donald J. MacIntyre,Dean F. MacKinnon,Robert Maier,Wolfgang Maier,Jonathan Marchini,Hamdi Mbarek,Patrick J. McGrath,Peter McGuffin,Sarah E. Medland,Divya Mehta,Divya Mehta,Christel M. Middeldorp,Christel M. Middeldorp,Evelin Mihailov,Yuri Milaneschi,Lili Milani,Jonathan Mill,Francis M. Mondimore,Grant W. Montgomery,Sara Mostafavi,Niamh Mullins,Matthias Nauck,Bernard Ng,Michel G. Nivard,Dale R. Nyholt,Paul F. O'Reilly,Hogni Oskarsson,Michael John Owen,Jodie N. Painter,Carsten Bøcker Pedersen,Carsten Bøcker Pedersen,Marianne Giørtz Pedersen,Marianne Giørtz Pedersen,Roseann E. Peterson,Erik Pettersson,Wouter J. Peyrot,Giorgio Pistis,Danielle Posthuma,Shaun Purcell,Jorge A. Quiroz,Per Qvist,Per Qvist,John P. Rice,Brien P. Riley,Margarita Rivera,Margarita Rivera,Saira Saeed Mirza,Richa Saxena,Richa Saxena,Robert A. Schoevers,Eva C. Schulte,Ling Shen,Jianxin Shi,Stanley I. Shyn,Engilbert Sigurdsson,Grant Sinnamon,Johannes H. Smit,Daniel J. Smith,Hreinn Stefansson,Stacy Steinberg,Craig A. Stockmeier,Fabian Streit,Jana Strohmaier,Katherine E. Tansey,Henning Teismann,Alexander Teumer,Wesley K. Thompson,Pippa A. Thomson,Thorgeir E. Thorgeirsson,Chao Tian,Matthew Traylor,Jens Treutlein,Vassily Trubetskoy,André G. Uitterlinden,Daniel Umbricht,Sandra Van der Auwera,Albert M. van Hemert,Alexander Viktorin,Peter M. Visscher,Yunpeng Wang,Yunpeng Wang,Yunpeng Wang,Bradley T. Webb,Shantel Weinsheimer,Shantel Weinsheimer,Jürgen Wellmann,Gonneke Willemsen,Stephanie H. Witt,Yang Wu,Hualin S. Xi,Jian Yang,Futao Zhang,Volker Arolt,Bernhard T. Baune,Klaus Berger,Dorret I. Boomsma,Sven Cichon,Udo Dannlowski,E. C.J. De Geus,J. Raymond DePaulo,Enrico Domenici,Katharina Domschke,Tõnu Esko,Tõnu Esko,Hans J. Grabe,Steven P. Hamilton,Caroline Hayward,Andrew C. Heath,David A. Hinds,Kenneth S. Kendler,Stefan Kloiber,Stefan Kloiber,Stefan Kloiber,Glyn Lewis,Qingqin S. Li,Susanne Lucae,Pamela F.A. Madden,Patrik K. E. Magnusson,Nicholas G. Martin,Andrew M. McIntosh,Andres Metspalu,Ole Mors,Ole Mors,Preben Bo Mortensen,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Merete Nordentoft,Merete Nordentoft,Markus M. Nöthen,Michael Conlon O'Donovan,Sara A. Paciga,Nancy L. Pedersen,Brenda W.J.H. Penninx,Roy H. Perlis,David J. Porteous,James B. Potash,Martin Preisig,Marcella Rietschel,Catherine Schaefer,Thomas G. Schulze,Jordan W. Smoller,Jordan W. Smoller,Kari Stefansson,Kari Stefansson,Henning Tiemeier,Rudolf Uher,Henry Völzke,Myrna M. Weissman,Myrna M. Weissman,Thomas Werge,Thomas Werge,Thomas Werge,Ashley R. Winslow,Ashley R. Winslow,Cathryn M. Lewis,Douglas F. Levinson,Gerome Breen,Anders D. Børglum,Anders D. Børglum,Patrick F. Sullivan,Patrick F. Sullivan +262 more
TL;DR: A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent and significant loci and finds important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia.
Journal ArticleDOI
Molecular Signatures of Major Depression
Na Cai,Simon Chang,Yihan Li,Qiban Li,Jingchu Hu,Jieqin Liang,Li Song,Warren W. Kretzschmar,Xiangchao Gan,Jérôme Nicod,Margarita Rivera,Margarita Rivera,Margarita Rivera,Hong Deng,Bo Du,Keqing Li,Wenhu Sang,Jingfang Gao,Shugui Gao,Baowei Ha,Hung-Yao Ho,Chunmei Hu,Jian Hu,Zhenfei Hu,Guoping Huang,Guoqing Jiang,Tao Jiang,Wei Jin,Gongying Li,Kan Li,Yi Li,Yingrui Li,Youhui Li,Yu-Ting Lin,Lanfen Liu,Tiebang Liu,Liu Ying,Yuan Liu,Yao Lu,L Lv,Huaqing Meng,Puyi Qian,Hong Sang,Jianhua Shen,Jianguo Shi,Sun Jing,Ming Tao,Gang Wang,Guangbiao Wang,Jian Wang,Linmao Wang,Xueyi Wang,Xumei Wang,Huanming Yang,Lijun Yang,Ye Yin,Jinbei Zhang,Kerang Zhang,Ning Sun,Wei Zhang,Xiuqing Zhang,Zhen Zhang,Hui Zhong,Gerome Breen,Gerome Breen,Jun Wang,Jonathan Marchini,Jonathan Marchini,Yiping Chen,Qi Xu,Xun Xu,Richard Mott,Guo-Jen Huang,Kenneth S. Kendler,Jonathan Flint,Jonathan Flint +75 more
TL;DR: It is demonstrated that changes in the amount of mtDNA and telomere length are consequences of stress and entering a depressed state and have important implications for understanding how stress causes the disease.
Journal ArticleDOI
Genetic Control over mtDNA and Its Relationship to Major Depressive Disorder
Na Cai,Yihan Li,Simon Chang,Jieqin Liang,Chongyun Lin,Xiufei Zhang,Lu Liang,Jingchu Hu,Wharton Chan,Kenneth S. Kendler,Tomas Malinauskas,Guo-Jen Huang,Qibin Li,Richard Mott,Jonathan Flint +14 more
TL;DR: Findings indicate the involvement of mitochondrial genome copy number and sequence in an organism’s response to stress, and identify increased rates of heteroplasmy in women with MDD.
Journal ArticleDOI
The Genetic Architecture of Major Depressive Disorder in Han Chinese Women.
Roseann E. Peterson,Na Cai,Tim B. Bigdeli,Yihan Li,Mark Reimers,Anna A. Nikulova,Bradley T. Webb,Silviu Alin Bacanu,Brien P. Riley,Jonathan Flint,Kenneth S. Kendler +10 more
TL;DR: Results support a complex etiology for MDD and highlight the value of analyzing components of heritability to clarify genetic architecture.
Journal ArticleDOI
Subtypes of major depression: latent class analysis in depressed Han Chinese women.
Yihan Li,Steven H. Aggen,Shenxun Shi,Jun Gao,Ming Tao,Kerang Zhang,X Wang,Chengge Gao,Lijun Yang,Liu Ying,Keqing Li,Jianguo Shi,Gang Wang,Lanfen Liu,J Zhang,Bo Du,Guoqing Jiang,Jianhua Shen,Zhiyong Zhang,Wei Liang,Sun Jing,Jian Hu,Tieqiao Liu,Guodong Miao,Huaqing Meng,Chunmei Hu,Guangshun Huang,Gongying Li,Baowei Ha,Hong Deng,Qiyi Mei,Hui Zhong,Shugui Gao,Hong Sang,Yutang Zhang,Xiang Fang,Fengyu Yu,Donglin Yang,Yunchun Chen,Xiaohong Hong,Wenyuan Wu,Gang Chen,Min Cai,Yan Song,Jiyang Pan,Jicheng Dong,Runde Pan,Wei Zhang,Zhenming Shen,Z. X. Liu,Danhua Gu,Xiaojuan Liu,Qiwen Zhang,Jonathan Flint,Kenneth S. Kendler +54 more
TL;DR: Three subtypes were most consistently identified in analyses: severe, atypical and non-suicidal, which may represent a pathoplastic variant reflecting Chinese cultural influences.