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Yijuang Chern
Researcher at Academia Sinica
Publications - 146
Citations - 5496
Yijuang Chern is an academic researcher from Academia Sinica. The author has contributed to research in topics: Huntington's disease & Huntingtin. The author has an hindex of 43, co-authored 138 publications receiving 4832 citations. Previous affiliations of Yijuang Chern include University of Massachusetts Amherst & Mayo Clinic.
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Aspects of the general biology of adenosine A2A signaling.
TL;DR: Many of the current hopes of finding better ways to treat Parkinson's disease or to stop its progression rely on studies of adenosine A2A receptors in the brain, yet any drug targeting central receptors will also potentially affect receptors in other sites.
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A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease
Han-Yun Hsiao,Yu-Chen Chen,Yu-Chen Chen,Hui-Mei Chen,Pang-Hsien Tu,Yijuang Chern,Yijuang Chern +6 more
TL;DR: The results indicate that enhancement of the p65-mediated inflammatory response in astrocytes contributes to HD pathogenesis andTherapeutic interventions aimed at preventing neuronal inflammation may be an important strategy for treating HD.
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CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model.
Szu Yi Chou,Yi Chao Lee,Hui Mei Chen,Ming Chang Chiang,Ming Chang Chiang,Hsing Lin Lai,Hao Hung Chang,Yi Chih Wu,Chung Nan Sun,Chen Li Chien,Yow-Sien Lin,Shyi-Chyi Wang,Shyi-Chyi Wang,Yu Ying Tung,Chen Chang,Yijuang Chern,Yijuang Chern,Yijuang Chern +17 more
TL;DR: In an HD transgenic mouse model (R6/2), daily administration of CGS21680 (CGS), an A2A adenosine receptor (A2A‐R)‐selective agonist, delayed the progressive deterioration of motor performance and prevented a reduction in brain weight.
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Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease
Tz Chuen Ju,Tz Chuen Ju,Hui Mei Chen,Jiun Tsai Lin,Ching Pang Chang,Wei Cheng Chang,Jheng Jie Kang,Cheng Pu Sun,Mi-Hua Tao,Pang-Hsien Tu,Chen Chang,Dennis W. Dickson,Yijuang Chern,Yijuang Chern +13 more
TL;DR: Nuclear accumulation of AMPK-α1 induces brain atrophy, neuronal loss, and formation of Htt aggregates in a Huntington’s disease model.
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Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease
Jian Jing Siew,Jian Jing Siew,Hui Mei Chen,Huan Yuan Chen,Hung-Lin Chen,Chiung Mei Chen,Bing-Wen Soong,Bing-Wen Soong,Yih Ru Wu,Ching Pang Chang,Yi Chen Chan,Chun-Hung Lin,Fu-Tong Liu,Fu-Tong Liu,Yijuang Chern,Yijuang Chern +15 more
TL;DR: In this paper, the authors showed that the plasma Gal3 levels of patients and mice correlated with disease severity, and that suppression of Gal3 ameliorated microglia-mediated pathogenesis, which suggests that Gal3 is a novel druggable target for HD.