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Ying-Tong Di

Bio: Ying-Tong Di is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Daphniphyllum & Trigonostemon. The author has an hindex of 29, co-authored 154 publications receiving 3066 citations.


Papers
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TL;DR: It is shown that PKC couples activation of the TFEB transcription factor with inactivation of the ZKSCAN3 transcriptional repressor through two parallel signalling cascades, which suggests PKC activation may mediate lysosomal adaptation to many extracellular cues.
Abstract: Lysosomes respond to environmental cues by controlling their own biogenesis, but the underlying mechanisms are poorly understood. Here we describe a protein kinase C (PKC)-dependent and mTORC1-independent mechanism for regulating lysosome biogenesis, which provides insights into previously reported effects of PKC on lysosomes. By identifying lysosome-inducing compounds we show that PKC couples activation of the TFEB transcription factor with inactivation of the ZKSCAN3 transcriptional repressor through two parallel signalling cascades. Activated PKC inactivates GSK3β, leading to reduced phosphorylation, nuclear translocation and activation of TFEB, while PKC activates JNK and p38 MAPK, which phosphorylate ZKSCAN3, leading to its inactivation by translocation out of the nucleus. PKC activation may therefore mediate lysosomal adaptation to many extracellular cues. PKC activators facilitate clearance of aggregated proteins and lipid droplets in cell models and ameliorate amyloid β plaque formation in APP/PS1 mouse brains. Thus, PKC activators are viable treatment options for lysosome-related disorders.

254 citations

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TL;DR: Three unprecedented indole alkaloids, trigonoliimines A-C (1-3) with a unique polycyclic system, were isolated from the leaves of Trigonostemon lii Y. T. Chang.

115 citations

Journal ArticleDOI
TL;DR: To the authors' knowledge, this is the first report on anti-TMV activity of beta-carbolines and their synergistic effects against TMV when combined with a quassinoid.
Abstract: To investigate natural inhibitors against tobacco mosaic virus (TMV) from plants, 10 known β-carboline alkaloids and one quassinoid have been isolated from MeOH extract of the wood of Picrasma quassioides Benn. These compounds were screened for their inhibitory activities against tobacco mosaic virus (TMV). The activity of each compound against TMV infection and replication was tested using a half-leaf assay method, a leaf-disk method, and Western blotting analyses. All of the β-carboline alkaloids showed moderate anti-TMV activities and exhibited synergistic effects when combined with the quassinoid nigakilactone B (11). To our knowledge, this is the first report on anti-TMV activity of β-carbolines and their synergistic effects against TMV when combined with a quassinoid.

106 citations

Journal ArticleDOI
TL;DR: The antiviral structure-activity relationships of quassinoids against TMV were discussed and eight compounds showed strong antiviral activities, with IC(50) values in the range of 3.42-5.66 microM.
Abstract: Two new quassinoids, javanicolide E (1) and javanicolide F (2), along with fifteen known C-20 quassinoids were isolated from the seeds of Brucea javanica (L.) Merr. The antitobacco, mosaic virus (TMV) activity of these quassinoids was screened by the conventional half-leaf and leaf-disk method along with Western blot analysis. All of the seventeen quassinoids showed potent anti-TMV activity. Among them, eight compounds, brusatol (3), bruceine B (4), bruceoside B (5), yadanzioside 1 (6), yaclanzioside L (7), bruceine D (8), yadanziolide A (9), and aglycone of yadanziolide D (17), showed strong antiviral activities, with IC(50) values in the range of 3.42-5.66 mu M, and were much more effective than the positive control, ningnanmycin (IC(50) = 117.3 mu M). The antiviral structure-activity relationships of quassinoids against TMV were also discussed.

104 citations

Journal ArticleDOI
TL;DR: The significant antifeedant activity of 1 against the generalist plant-feeding insect Helicoverpa armigera suggested it may be a potent defensive component of A. polystachya.

89 citations


Cited by
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01 Dec 2007

1,121 citations

Journal ArticleDOI
01 Dec 2008

636 citations

Journal ArticleDOI
TL;DR: The applications of gold catalysed reactions in total synthesis during the years since the last article are reviewed and literature analysis is conducted to evaluate the progress in this field.
Abstract: In this critical review the applications of gold catalysed reactions in total synthesis during the years since our last article are reviewed. At the end of this article a literature analysis is conducted to evaluate the progress in this field.

617 citations

Journal ArticleDOI
TL;DR: The modulation of lysosome function could be a promising therapeutic strategy for the treatment of cancer as well as metabolic and neurodegenerative disorders.
Abstract: Exciting new discoveries have transformed the view of the lysosome from a static organelle dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that mediates the adaptation of cell metabolism to environmental cues. Lysosome-mediated signalling pathways and transcription programmes are able to sense the status of cellular metabolism and control the switch between anabolism and catabolism by regulating lysosomal biogenesis and autophagy. The lysosome also extensively communicates with other cellular structures by exchanging content and information and by establishing membrane contact sites. It is now clear that lysosome positioning is a dynamically regulated process and a crucial determinant of lysosomal function. Finally, growing evidence indicates that the role of lysosomal dysfunction in human diseases goes beyond rare inherited diseases, such as lysosomal storage disorders, to include common neurodegenerative and metabolic diseases, as well as cancer. Together, these discoveries highlight the lysosome as a regulatory hub for cellular and organismal homeostasis, and an attractive therapeutic target for a broad variety of disease conditions.

602 citations

Journal ArticleDOI
TL;DR: This review focused on the recent development of indole derivatives as antiviral agents and summarized the structure property, hoping to inspire new and even more creative approaches to discover novel drugs with different modes of action.

575 citations