Y
Yingming Zhao
Researcher at University of Chicago
Publications - 207
Citations - 36298
Yingming Zhao is an academic researcher from University of Chicago. The author has contributed to research in topics: Acetylation & Lysine. The author has an hindex of 88, co-authored 200 publications receiving 30662 citations. Previous affiliations of Yingming Zhao include Icahn School of Medicine at Mount Sinai & Rockefeller University.
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Journal ArticleDOI
Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey
Sung Chan Kim,Robert Sprung,Yue Chen,Yingda Xu,Haydn L. Ball,Jimin Pei,Tzuling Cheng,Yoonjung Kho,Hao Xiao,Lin Xiao,Nick V. Grishin,Michael A. White,Xiang-Jiao Yang,Yingming Zhao +13 more
TL;DR: This study reveals previously unappreciated roles for lysine acetylation in the regulation of diverse cellular pathways outside of the nucleus, including many longevity regulators and metabolism enzymes.
Journal ArticleDOI
Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
Minjia Tan,Hao Luo,Sangkyu Lee,Fulai Jin,Jeong Soo Yang,Emilie Montellier,Thierry Buchou,Zhongyi Cheng,Sophie Rousseaux,Nisha Rajagopal,Zhike Lu,Zhen Ye,Qin Zhu,Joanna Wysocka,Yang Ye,Saadi Khochbin,Bing Ren,Yingming Zhao +17 more
TL;DR: The identification of 67 previously undescribed histone modifications is reported, increasing the current number of known histone marks by about 70%, and lysine crotonylation (Kcr) is investigated, confirming that it represents an evolutionarily-conserved histone posttranslational modification.
Journal ArticleDOI
The Yeast Nuclear Pore Complex: Composition, Architecture, and Transport Mechanism
Michael P. Rout,John D. Aitchison,Adisetyantari Suprapto,Kelly Hjertaas,Yingming Zhao,Brian T. Chait +5 more
TL;DR: In this paper, a comprehensive approach to classify all components of the yeast NPC (nucleoporins) was taken, which involved identifying all the proteins present in a highly enriched NPC fraction, determining which of these proteins were nucleopors, and localizing each nucleoporin within the NPC.
Journal ArticleDOI
Proteogenomic characterization of human colon and rectal cancer
Bing Zhang,Jing Wang,Xiaojing Wang,Jing Zhu,Qi Liu,Zhiao Shi,Matthew C. Chambers,Lisa J. Zimmerman,Kent Shaddox,Sangtae Kim,Sherri R. Davies,Sean Wang,Pei Wang,Christopher R. Kinsinger,Robert Rivers,Henry Rodriguez,R. Reid Townsend,Matthew J. Ellis,Steven A. Carr,Steven A. Carr,David L. Tabb,Robert J. Coffey,Robbert J.C. Slebos,Daniel C. Liebler,Michael A. Gillette,Karl R. Klauser,Eric Kuhn,D. R. Mani,Philipp Mertins,Karen A. Ketchum,Amanda G. Paulovich,Jeffrey R. Whiteaker,Nathan Edwards,Peter B. McGarvey,Subha Madhavan,Daniel W. Chan,Akhilesh Pandey,Ie Ming Shih,Hui Zhang,Zhen Zhang,Heng Zhu,Gordon Whiteley,Steven J. Skates,Forest M. White,Douglas A. Levine,Emily S. Boja,Tara Hiltke,Mehdi Mesri,Kenna M. Shaw,Stephen E. Stein,David Fenyö,Tao Liu,Jason E. McDermott,Samuel H. Payne,Karin D. Rodland,Richard D. Smith,Paul A. Rudnick,Michael Snyder,Yingming Zhao,Xian Chen,David F. Ransohoff,Andrew N. Hoofnagle,Melinda E. Sanders,Yue Wang,Li Ding +64 more
TL;DR: Integrated proteogenomic analysis provides functional context to interpret genomic abnormalities and affords a new paradigm for understanding cancer biology.
Journal ArticleDOI
Metabolic regulation of gene expression by histone lactylation
Di Zhang,Zhanyun Tang,He Huang,He Huang,Guolin Zhou,Chang Cui,Yejing Weng,Wenchao Liu,Sunjoo Kim,Sangkyu Lee,Mathew Perez-Neut,Jun Ding,Daniel M. Czyż,Rong Hu,Zhen Ye,Maomao He,Y. George Zheng,Howard A. Shuman,Lunzhi Dai,Lunzhi Dai,Bing Ren,Robert G. Roeder,Lev Becker,Yingming Zhao +23 more
TL;DR: The results suggest that an endogenous ‘lactate clock’ in bacterially challenged M1 macrophages turns on gene expression to promote homeostasis, and represents an opportunity to improve the understanding of the functions of lactate and its role in diverse pathophysiological conditions, including infection and cancer.