Yingyu Huang

TL;DR: Curcumin derivative C1 is identified as a novel MTOR-independent activator of TFEB, which enhances autophagy and lysosome biogenesis in vitro and in vivo and is a potential therapeutic agent for the treatment of neurodegenerative diseases.

TL;DR: The body produces significant evidence of metabolic disorder during SIRS or sepsis, such that S-(3-methylbutanoyl)-dihydrolipoamide-E, phosphatidylglycerol and S-succinyl glutathione were significantly decreased.

TL;DR: Tianma Gouteng Yin is neuroprotective in PD models both in vivo and in vitro and prevents degeneration of dopaminergic neurons.

TL;DR: The results suggest that targeting the ALP with natural products is a promising strategy for PD treatment, and Rigorous experimental design following the guidelines of autophagy assays, molecular target identification and in vivo efficacy evaluation is critical for the development of ALP enhancers forPD treatment in future studies.

TL;DR: Traditional Chinese medicine herbs target pathways such as Notch, Wnt, Sonic Hedgehog and receptor tyrosine kinase pathway, leading to activation of a signaling cascade that ultimately enhances the transcription of several important genes necessary for neurogenesis.