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Yingzhuo Grace Yan
Researcher at Bristol-Myers Squibb
Publications - 2
Citations - 34
Yingzhuo Grace Yan is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Active metabolite & Receptor. The author has an hindex of 1, co-authored 2 publications receiving 5 citations.
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Journal ArticleDOI
Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator.
Sekhar Surapaneni,Usha Yerramilli,April Bai,Deepak Dalvie,Jennifer Brooks,Xiaomin Wang,Julie V. Selkirk,Yingzhuo Grace Yan,Peijin Zhang,Richard Hargreaves,Gondi Kumar,Maria Palmisano,Jonathan Q. Tran +12 more
TL;DR: Ozanimod was extensively metabolized, with 14 metabolites identified, including two major active metabolites (CC112273 and CC1084037) and one major inactive metabolite (RP101124) in circulation as discussed by the authors.
Journal ArticleDOI
Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5.
Julie V. Selkirk,Kevin C. Dines,Yingzhuo Grace Yan,Nathan Ching,Deepak Dalvie,Shameek Biswas,Andrea Bortolato,Jeffrey M. Schkeryantz,Carlos Lopez,Iliana Ruiz,Richard Hargreaves +10 more
TL;DR: Ozanimod, a selective modulator of human sphingisone 1-phosphate receptor subtypes 1 and 5 (S1P1/5), displays reduced potency for rodent and dog S1P5 compared with human, which results from mutation of threonine to alanine at position 120.