Author
Yinmei Li
Bio: Yinmei Li is an academic researcher from University of Science and Technology of China. The author has contributed to research in topics: Optical tweezers & Digital micromirror device. The author has an hindex of 18, co-authored 81 publications receiving 1171 citations.
Papers published on a yearly basis
Papers
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TL;DR: This work uses infrared optical tweezers to trap and manipulate red blood cells within subdermal capillaries in living mice and realizes a non-contact micro-operation that results in the clearing of a blocked microvessel.
Abstract: The recent development of non-invasive imaging techniques has enabled the visualization of molecular events underlying cellular processes in live cells Although microscopic objects can be readily manipulated at the cellular level, additional physiological insight is likely to be gained by manipulation of cells in vivo, which has not been achieved so far Here we use infrared optical tweezers to trap and manipulate red blood cells within subdermal capillaries in living mice We realize a non-contact micro-operation that results in the clearing of a blocked microvessel Furthermore, we estimate the optical trap stiffness in the capillary Our work expands the application of optical tweezers to the study of live cell dynamics in animals
306 citations
TL;DR: A novel scattering-matrix-assisted retrieval technique (SMART) to demultiplex OAM channels from highly scattered optical fields is proposed and high-fidelity transmission of both gray and color images under scattering conditions is demonstrated, reducing the error rate by 21 times compared to previous reports.
Abstract: Multiplexing multiple orbital angular momentum (OAM) channels enables high-capacity optical communication. However, optical scattering from ambient microparticles in the atmosphere or mode coupling in optical fibers significantly decreases the orthogonality between OAM channels for demultiplexing and eventually increases crosstalk in communication. Here, we propose a novel scattering-matrix-assisted retrieval technique (SMART) to demultiplex OAM channels from highly scattered optical fields and achieve an experimental crosstalk of –13.8 dB in the parallel sorting of 24 OAM channels after passing through a scattering medium. The SMART is implemented in a self-built data transmission system that employs a digital micromirror device to encode OAM channels and realize reference-free calibration simultaneously, thereby enabling a high tolerance to misalignment. We successfully demonstrate high-fidelity transmission of both gray and color images under scattering conditions at an error rate of <0.08%. This technique might open the door to high-performance optical communication in turbulent environments.
147 citations
TL;DR: These observations demonstrate that the DMD offers a simple and efficient method to generate Bessel beams with distinct nondiffracting and self-reconstruction behaviors, and will potentially expand the applications to the optical manipulation and high-resolution fluorescence imaging owing to the unique nondIFFracting property.
Abstract: We experimentally demonstrated Bessel-like beams utilizing digital micromirror device (DMD). DMD with images imitating the equivalent axicon can shape the collimated Gaussian beam into Bessel beam. We reconstructed the 3D spatial field of the generated beam through a stack of measured cross-sectional images. The output beams have the profile of Bessel function after intensity modulation, and the beams extend at least 50 mm while the lateral dimension of the spot remains nearly invariant. Furthermore, the self-healing property has also been investigated, and all the experimental results agree well with simulated results numerically calculated through beam propagation method. Our observations demonstrate that the DMD offers a simple and efficient method to generate Bessel beams with distinct nondiffracting and self-reconstruction behaviors. The generated Bessel beams will potentially expand the applications to the optical manipulation and high-resolution fluorescence imaging owing to the unique nondiffracting property.
65 citations
TL;DR: In this article, the authors proposed a method to directly transform a linearly polarized Gaussian beam into vector-vortex beams with various spatial patterns via a Digital Micro-mirror Device (DMD) binary holography for generating Laguerre Gaussian, Bessel Gaussian and helical Mathieu Gaussian modes, while a radial polarization converter (S-waveplate) is employed to effectively convert the optical vortices into cylindrically polarized vortex beams.
Abstract: We propose a novel technique to directly transform a linearly polarized Gaussian beam into vector-vortex beams with various spatial patterns. Full high-quality control of amplitude and phase is implemented via a Digital Micro-mirror Device (DMD) binary holography for generating Laguerre-Gaussian, Bessel-Gaussian, and helical Mathieu–Gaussian modes, while a radial polarization converter (S-waveplate) is employed to effectively convert the optical vortices into cylindrically polarized vortex beams. Additionally, the generated vector-vortex beams maintain their polarization symmetry after arbitrary polarization manipulation. Due to the high frame rates of DMD, rapid switching among a series of vector modes carrying different orbital angular momenta paves the way for optical microscopy, trapping, and communication.
63 citations
TL;DR: In this paper, a photoinduced reversible isomerization of azopyridine units in PNIPAM-b-PAzPy vesicles was observed under an optical microscope.
Abstract: Poly(N-isopropylacrylamide)-block-poly{6-[4-(4-pyridyazo)phenoxy] hexylmethacrylate} (PNIPAM-b-PAzPy) was synthesized by successive reversible addition-fragmentation chain transfer (RAFT) polymerization. In a water/tetrahydrofuran (H 2 O/THF) mixture, amphiphilic PNIPAM-b-PAzPy self-assembles into giant micro-vesicles. Upon alternate ultraviolet (UV) and visible light irradiation, obvious reversible swelling-shrinking of the vesicles was observed directly under an optical microscope. The maximum percentage increase in volume, caused by the UV light, reached 17%. Moreover, the swelling could be adjusted using the UV light power density. The derivation of this effect is due to photoinduced reversible isomerization of azopyridine units in the vesicles.
55 citations
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TL;DR: There has been considerable interest in the application of photochromism to photo-responsive systems which has led to the development of new tailored smart materials for photonics and biomedical fields as discussed by the authors, and the underlying principles behind photoresponsive behavior, subsequent applications and relevant examples.
475 citations
TL;DR: The different approaches of rational BCP design, making use of various photochromic moieties and photochemical reactions, and the underlying mechanisms leading to photoinduced disruption of BCP micelles are discussed.
Abstract: The association state of light-responsive block copolymer (BCP) micelles in aqueous solution can be altered, often reversibly, by light. Driven by the potential application in controlled drug delivery, this type of stimuli-responsive polymer micelles has received increasing attention. This Perspective highlights the progress achieved in recent years. On the one hand, we discuss the different approaches of rational BCP design, making use of various photochromic moieties and photochemical reactions, and the underlying mechanisms leading to photoinduced disruption of BCP micelles. On the other hand, we suggest possible future directions in this area, including exploration of new mechanisms and chemistry and solutions to the excitation wavelength problem crucial for biomedical applications.
462 citations
TL;DR: This tutorial review provides some guidelines towards the rational design of photo-responsive block copolymers and presents the different photo- responsive moieties that have been used so far and suggests possible future developments including the design of biocompatible systems operating at excitation wavelengths compatible for biomedical applications.
Abstract: Stimuli-responsive block copolymer micelles are the topic of intense research since they are able to show sharp and eventually reversible responses to various environmental changes and find applications in various fields including controlled drug delivery. Among all the available stimuli, light has recently attracted much attention since it can be localized in time and space, and it can also be triggered from outside of the system. In this tutorial review, we highlight the progress realized in recent years. More precisely, we provide some guidelines towards the rational design of photo-responsive block copolymers and we present the different photo-responsive moieties that have been used so far. We also discuss the different types of irreversible and reversible responses encountered by photo-responsive block copolymer micelles. Finally, we suggest possible future developments including the design of biocompatible systems operating at excitation wavelengths compatible for biomedical applications.
452 citations
TL;DR: A new method for the patterning of multiple spatially separated single particles and cells using high-frequency acoustic fields with one cell per acoustic well is introduced, made possible by a hitherto unexplored regime where the acoustic wavelength is on the same order as the cell dimensions.
Abstract: In single-cell analysis, cellular activity and parameters are assayed on an individual, rather than population-average basis. Essential to observing the activity of these cells over time is the ability to trap, pattern and retain them, for which previous single-cell-patterning work has principally made use of mechanical methods. While successful as a long-term cell-patterning strategy, these devices remain essentially single use. Here we introduce a new method for the patterning of multiple spatially separated single particles and cells using high-frequency acoustic fields with one cell per acoustic well. We characterize and demonstrate patterning for both a range of particle sizes and the capture and patterning of cells, including human lymphocytes and red blood cells infected by the malarial parasite Plasmodium falciparum. This ability is made possible by a hitherto unexplored regime where the acoustic wavelength is on the same order as the cell dimensions.
415 citations
01 Mar 2000
TL;DR: This work uses multispeckle dynamic light scattering to measure the dynamic structure factor, f(q,tau), of gels formed by aggregation of colloids, offering convincing proof of the universality of these concepts.
Abstract: We use multispeckle dynamic light scattering to measure the dynamic structure factor, f(q,tau), of gels formed by aggregation of colloids. Although the gel is an elastic solid, f(q,tau) nearly completely decays on long time scales, with an unusual form, f(q, tau) approximately exp{-(tau/tau(f))(mu)}, with mu approximately 1.5 and with tau(f) proportional variant q(-1). A model for restructuring of the gel with aging correctly accounts for this behavior. Aging leads to a dramatic increase in tau(f); however, all data can be scaled on a single master curve, with tau(f) asymptotically growing linearly with age. This behavior is strikingly similar to that predicted for aging in disordered glassy systems, offering convincing proof of the universality of these concepts.
348 citations