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Yixin Wang
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 101
Citations - 15619
Yixin Wang is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 38, co-authored 87 publications receiving 13630 citations. Previous affiliations of Yixin Wang include Johnson & Johnson & University of Ljubljana.
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Journal ArticleDOI
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer.
Yixin Wang,Jan Klijn,Yi Zhang,Anieta M. Sieuwerts,Maxime P. Look,Fei Yang,Dmitri Talantov,Mieke Timmermans,Marion E. Meijer-van Gelder,Jack X. Yu,Tim Jatkoe,Els M.J.J. Berns,David Atkins,John A. Foekens +13 more
TL;DR: The ability to identify patients who have a favourable prognosis could, after independent confirmation, allow clinicians to avoid adjuvant systemic therapy or to choose less aggressive therapeutic options.
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Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials.
Richard Peto,C Davies,Jon Godwin,Richard Gray,Hongchao Pan,Mike Clarke,D Cutter,Sarah C. Darby,Paul McGale,Carolyn W. Taylor,Yixin Wang,Jonas Bergh,A. Di Leo,KS Albain,Sandra M. Swain,M.J. Piccart,Kathleen I. Pritchard +16 more
TL;DR: In meta-analyses involving taxane-based or anthracycline-based regimens, proportional risk reductions were little affected by age, nodal status, tumour diameter or differentiation (moderate or poor; few were well differentiated), oestrogen receptor status, or tamoxifen use.
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Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials
Paul McGale,Carolyn W. Taylor,C Correa,D Cutter,F Duane,Marianne Ewertz,Richard Gray,Gurdeep S. Mannu,Richard Peto,Timothy J. Whelan,Yixin Wang,Zhe Wang,Sarah C. Darby +12 more
TL;DR: After mastectomy and axillary dissection, radiotherapy reduced both recurrence and breast cancer mortality in the women with one to three positive lymph nodes in these trials even when systemic therapy was given.
Journal ArticleDOI
Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series,
Christine Desmedt,Fanny Piette,Sherene Loi,Yixin Wang,Françoise Lallemand,Benjamin Haibe-Kains,Giuseppe Viale,Mauro Delorenzi,Yi Zhang,Mahasti Saghatchian d'Assignies,Jonas Bergh,Rosette Lidereau,Paul Ellis,Adrian L. Harris,Jan Klijn,John A. Foekens,Fatima Cardoso,Martine Piccart,Marc Buyse,Christos Sotiriou +19 more
TL;DR: This independent validation confirmed the performance of the 76-gene signature and adds to the growing evidence that gene expression signatures are of clinical relevance, especially for identifying patients at high risk of early distant metastases.
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Young Age at Diagnosis Correlates With Worse Prognosis and Defines a Subset of Breast Cancers With Shared Patterns of Gene Expression
Carey K. Anders,David S. Hsu,Gloria Broadwater,Chaitanya R. Acharya,John A. Foekens,Yi Zhang,Yixin Wang,P. Kelly Marcom,Jeffrey R. Marks,Phillip G. Febbo,Joseph R. Nevins,Anil Potti,Kimberly L. Blackwell +12 more
TL;DR: This large-scale genomic analysis illustrates that breast cancer arising in young women is a unique biologic entity driven by unifying oncogenic signaling pathways, is characterized by less hormone sensitivity and higher HER-2/EGFR expression, and warrants further study to offer this poor-prognosis group of women better preventative and therapeutic options.