Yiyan Fei

TL;DR: Compounds that interact with mutant huntingtin and an autophagosomal protein are able to reduce cellular levels of mutant Huntingtin by targeting it for autophagic degradation, demonstrating an approach that may have potential for treating proteopathies.

TL;DR: In this article, the authors review key emerging technologies that exploit the lysosomal degradation pathway and discuss their potential applications and limitations, as well as emerging new degrader technologies may greatly broaden the spectrum of targets that could be selectively degraded by harnessing a second major degradation pathway in cells.

TL;DR: This study provides the initial validation of lowering mHTT by ATTEC, providing entry points to new treatment strategies of HD and similar diseases.

TL;DR: The throughput of this binding curve assay platform is comparable to those at the National Institutes of Health Molecular Library Screening Centers, making it a practical method in screening compound libraries for novel ligands and for system-wide affinity profiling of proteins, viruses, or whole cells against diverse molecular targets.

TL;DR: A novel scanning optical microscope based on a polarization-modulated nulling ellipsometry that enables high-throughput label-free detection of biomolecular microarrays with more than 10 000 protein or small-molecule targets and is capable of determining real-time binding kinetics of multiple molecular species under aqueous conditions.