Yiying Zeng

Bio: Yiying Zeng is an academic researcher from Yanbian University. The author has contributed to research in topics: Electrochemiluminescence & Luminescence. The author has an hindex of 2, co-authored 3 publications receiving 221 citations.

A Fluorescent Sensor for Dual-Channel Discrimination between Phosgene and a Nerve-Gas Mimic

Abstract: The ability to analyze highly toxic chemical warfare agents (CWAs) and related chemicals in a rapid and precise manner is essential in order to alleviate serious threats to humankind and public security caused by unexpected terrorist attacks and industrial accidents. In this investigation, we designed a o-phenylenediamine-pyronin linked dye that is capable of both fluorogenic and colorimetric discrimination between phosgene and the prototypical nerve-agent mimic, diethyl chlorophosphate (DCP) in the solution or gas phase. Moreover, this dye has been used to construct a portable kit that can be employed for real-time monitoring of DCP and phosgene in the field, both in a discriminatory manner, and in a simple and safe way.

Effective Strategy for Colorimetric and Fluorescence Sensing of Phosgene Based on Small Organic Dyes and Nanofiber Platforms.

Abstract: Three o-phenylendiamine (OPD) derivatives, containing 4-chloro-7-nitrobenzo[c][1,2,5]oxadiazole (NBD-OPD), rhodamine (RB-OPD), and 1,8-naphthalimide (NAP-OPD) moieties, were prepared and tested as phosgene chemosensors. Unlike previously described methods to sense this toxic agent, which rely on chemical processes that transform alcohols and amines to respective phosphate esters and phosphoramides, the new sensors operate through a benzimidazolone-forming reaction between their OPD groups and phosgene. These processes promote either naked eye visible color changes and/or fluorescence intensity enhancements in conjunction with detection limits that range from 0.7 to 2.8 ppb. NBD-OPD and RB-OPD-embedded polymer fibers, prepared using the electrospinning technique, display distinct color and fluorescence changes upon exposure to phosgene even in the solid state.

Synthetic method of pyronine derivative dye

Abstract: The invention discloses a synthetic method of a pyronine derivative dye. The synthetic method comprises the following steps: with pyronine as a raw material, producing carbine serving as an intermediate under the action of potassium tert-butoxide, carrying out reaction on carbine and sulfur or oxygen to produce pyronine thione or ketone, and then carrying out reaction on pyronine thione and amine or halohydrocarbon to produce the pyronine derivative dye. The synthetic method is safe and simple in operation, short in reaction time and good in yield and purity of the pyronine derivative dye.

Pyronin Derivatives as Efficient Electrochemiluminescence Emitters in Aqueous Solution

Abstract: The electrochemiluminescence (ECL) behavior of pyronin derivatives was reported for the first time. We found that these derivatives, as novel ECL emitters, generated an efficient emission phenomenon; that is, they showed anodic emission using tri-propylamine (TPA) as the coreactant and cathodic ECL emission using K2S2O8 as the coreactant. Because of its remarkable luminescent performance, the ECL mechanism (reductive-oxidative and oxidative-reductive) of benzylthiol-substituted pyronin (BTP) was specifically studied. Surprisingly, the cathodic ECL emission of BTP had a lower ECL peak potential at -0.54 V (vs. SCE) in aqueous solution. The potential range of -0.7 V to 0.0 V is lower than that of previously reported K2S2O8 cathodic ECL systems. Its good water solubility, easy modification, and excellent emission properties facilitate appealing (bio)analytical applications in ECL biosensors and cell imaging.

Functional Synthetic Probes for Selective Targeting and Multi-analyte Detection and Imaging

Abstract: In contrast to the classical design of a probe with one binding site to target one specific analyte, probes with multiple interaction sites or, alternatively, with single sites promoting tandem reactions to target one or multiple analytes, have been developed. They have been used in addressing the inherent challenges of selective targeting in the presence of structurally similar compounds and in complex matrices, as well as the visualization of the in vivo interaction or crosstalk between the analytes. Examples of analytes include reactive sulfur species, reactive oxygen species, nucleotides and enzymes. This review focuses on recent innovations in probe design, detection mechanisms and the investigation of biological processes. The vision is to promote the ongoing development of fluorescent probes to enable deeper insight into the physiology of bioactive analytes.

Recent Advances in the Development of Chromophore-Based Chemosensors for Nerve Agents and Phosgene

Abstract: The extreme toxicity and ready accessibility of nerve agents and phosgene has caused an increase in the demand to develop effective systems for the detection of these substances. Among the traditional platforms utilized for this purpose, chemosensors including surface acoustic wave (SAW) sensors, enzymes, carbon nanotubes, nanoparticles, and chromophore based sensors have attracted increasing attention. In this review, we describe in a comprehensive manner recent progress that has been made on the development of chromophore-based chemosensors for detecting nerve agents (mimic) and phosgene. This review comprises two sections focusing on studies of the development of chemosensors for nerve agents (mimic) and phosgene. In each of the sections, the discussion follows a format which concentrates on different reaction sites/mechanisms involved in the sensing processes. Finally, chemosensors uncovered in these efforts are compared with those based on other sensing methods and challenges facing the design of mor...

Effective Strategy for Colorimetric and Fluorescence Sensing of Phosgene Based on Small Organic Dyes and Nanofiber Platforms.

Abstract: Three o-phenylendiamine (OPD) derivatives, containing 4-chloro-7-nitrobenzo[c][1,2,5]oxadiazole (NBD-OPD), rhodamine (RB-OPD), and 1,8-naphthalimide (NAP-OPD) moieties, were prepared and tested as phosgene chemosensors. Unlike previously described methods to sense this toxic agent, which rely on chemical processes that transform alcohols and amines to respective phosphate esters and phosphoramides, the new sensors operate through a benzimidazolone-forming reaction between their OPD groups and phosgene. These processes promote either naked eye visible color changes and/or fluorescence intensity enhancements in conjunction with detection limits that range from 0.7 to 2.8 ppb. NBD-OPD and RB-OPD-embedded polymer fibers, prepared using the electrospinning technique, display distinct color and fluorescence changes upon exposure to phosgene even in the solid state.

BODIPY-Based Fluorescent Sensor for the Recognization of Phosgene in Solutions and in Gas Phase

Abstract: As a highly toxic and widely used chemical, phosgene has become a serious threat to humankind and public security because of its potential use by terrorists and unexpected release during industrial accidents. For this reason, it is an urgent need to develop facile, fast, and selective detection methods of phosgene. In this Article, we have constructed a highly selective fluorescent sensor o-Pab for phosgene with a BODIPY unit as a fluorophore and o-phenylenediamine as a reactive site. The sensor o-Pab exhibits rapid response (∼15 s) in both colorimetric and turn-on fluorescence modes, high selectivity for phosgene over nerve agent mimics and various acyl chlorides and a low detection limit (2.7 nM) in solutions. In contrast to most undistinguishable sensors reported, o-Pab can react with phosgene but not with its substitutes, triphosgene and biphosgene. The excellent discrimination of o-Pab has been demonstrated to be due to the difference in highly reactive and bifunctional phosgene relative to its subst...