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Yogesh C. Awasthi
Researcher at University of North Texas Health Science Center
Publications - 254
Citations - 12701
Yogesh C. Awasthi is an academic researcher from University of North Texas Health Science Center. The author has contributed to research in topics: Glutathione & Glutathione S-transferase. The author has an hindex of 61, co-authored 254 publications receiving 12304 citations. Previous affiliations of Yogesh C. Awasthi include Saint Vincent Hospital & University of North Texas.
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Journal ArticleDOI
Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties
Piotr Zimniak,Bindu Nanduri,Slawomir Pikula,Joanna Bandorowicz-Pikula,Sharad S. Singhal,Sanjay K. Srivastava,Sanjay Awasthi,Yogesh C. Awasthi +7 more
TL;DR: Data indicate that the residue in position 104 helps to define the geometry of the hydrophobic substrate-binding site, and may also influence activity by interacting with residues directly involved in substrate binding.
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Role of glutathione S-transferases in protection against lipid peroxidation. Overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation.
Yusong Yang,Ji-Zhong Cheng,Sharad S. Singhal,Manjit K. Saini,Utpal Pandya,Sanjay Awasthi,Yogesh C. Awasthi +6 more
TL;DR: The physiological significance of the selenium-independent glutathione peroxidase (GPx) activity of the major Alpha class isoenzymes, associated with the major GSTs hGSTA1-1 and hGstA2-2, is not known as mentioned in this paper.
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Antioxidant Role of Glutathione S-Transferases: Protection Against Oxidant Toxicity and Regulation of Stress-Mediated Apoptosis
TL;DR: Evidence strongly suggests that lipid peroxidation products, particularly hydroperoxides and 4-HNE, are involved in the mechanisms of stress-mediated signaling and that it can be modulated by the Alpha class GSTs through the regulation of the intracellular concentrations of 4- HNE.
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Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases.
Yogesh C. Awasthi,Yusong Yang,Narendra K. Tiwari,Brad Patrick,Abha Sharma,Jie Li,Sanjay Awasthi +6 more
TL;DR: Recent studies from the laboratories strongly suggest that HNE is a key signaling molecule and that GSTs, being determinants of its intracellular concentrations, can regulate stress-mediated signaling.
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Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling.
TL;DR: Evidence demonstrating the modulation of UV, oxidative stress, and chemical stress mediated apoptosis by blocking lipid peroxidation by the alpha-class glutathione S-transferases (GSTs) is presented is presented which suggest an important role of these enzymes in protection against oxidative stress and a role of lipidperoxidation products in stress mediated signaling.