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Yongbin Wang
Researcher at Shanghai Jiao Tong University
Publications - 9
Citations - 532
Yongbin Wang is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 5, co-authored 7 publications receiving 408 citations.
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Journal ArticleDOI
Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Daoxiang Zhang,Daoxiang Zhang,Yongbin Wang,Zhimin Shi,Jingyi Liu,Pan Sun,Xiaodan Hou,Jian Zhang,Shimin Zhao,Binhua P. Zhou,Jun Mi +10 more
TL;DR: It is reported that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphorylation to aerobic glycolysis, and downregulation of isocitrate dehydrogenase 3α (IDH3α) is identified as a marker for this switch.
Journal ArticleDOI
MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation
Qiong Li,Daoxiang Zhang,Yongbin Wang,Pan Sun,Xiaodan Hou,James M. Larner,Wujun Xiong,Jun Mi,Jun Mi +8 more
TL;DR: It is demonstrated that miR-21 and Smad7 are critical regulators of TGF-β1 signaling during the induction of CAF formation.
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Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy.
Yongbin Wang,Guifang Gan,Wang Bocheng,Jinliang Wu,Yuan Cao,Dan Zhu,Yan Xu,Xiaona Wang,Hong-Xiu Han,Xiaoling Li,Ming Ye,Jiangmin Zhao,Jun Mi +12 more
TL;DR: It is demonstrated that cancer-associated fibroblasts promoted irradiated cancer cell recovery and tumor regrowth post-radiation, suggesting that targeting the autophagy pathway in tumor cells may be a promising therapeutic strategy for radiotherapy sensitization.
Journal ArticleDOI
Cysteine transporter SLC3A1 promotes breast cancer tumorigenesis.
TL;DR: It is demonstrated that the expression level of the solute carrier family 3, member 1 (SLC3A1), the cysteine carrier, tightly correlated with clinical stages and patients' survival, and is a potential therapeutic target for breast cancer.
Journal ArticleDOI
TGFBR-IDH1-Cav1 axis promotes TGF-β signalling in cancer-associated fibroblast
TL;DR: It is reported that the TGFBR-IDH1-Cav1 axis promotes TGF- β signalling in fibroblasts, and downregulation of IDH1 increased cellular concentration of α-ketoglutarate (α-KG) by accelerating glutamine metabolization.