Y
Yongchun Hou
Researcher at Wayne State University
Publications - 13
Citations - 652
Yongchun Hou is an academic researcher from Wayne State University. The author has contributed to research in topics: Alkylation & Cytotoxicity. The author has an hindex of 10, co-authored 13 publications receiving 621 citations.
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Journal ArticleDOI
Current Trends in the Development of Nitric Oxide Donors
TL;DR: General aspects on NO and NO donors are reviewed, major focus is placed on recent developments of novel NO donors, NO releasing device(s) as well as innovative improvements to current NO donors.
Journal Article
Current trends in the development of nitric oxide donors.
TL;DR: In this paper, a review of the state of the art on NO donors is presented, focusing on recent developments of novel NO donors, NO releasing device(s) as well as innovative improvements to current NO donors.
Journal ArticleDOI
Targeting nitric oxide to cancer cells: cytotoxicity studies of glyco-S-nitrosothiols.
Yongchun Hou,Jianqiang Wang,Peter R. Andreana,Guilleherme Cantauria,Srikumar Tarasia,Laura Sharp,Paul G. Braunschweiger,Peng George Wang +7 more
TL;DR: Glyco-S-nitrosothiols, fructose-2-SNAP and glucose-2,SNAP, were synthesized and found to be much more cytotoxic than SNAP in killing DU-145 human prostate cancer cells in vitro.
Journal ArticleDOI
Inhibition of protein tyrosine phosphatases by low-molecular-weight S-nitrosothiols and S-nitrosylated human serum albumin
Ming Xian,Kun Wang,Xinchao Chen,Yongchun Hou,Andrea McGill,Xi Chen,Bo Zhou,Zhong Yin Zhang,Jin Pei Cheng,Peng George Wang +9 more
TL;DR: Both single- and poly-S-nitrosylated human serum albumin show good inhibitory ability to Yersinia PTPase, indicating a possibility that S-nitrosothiols in vivo may function as an inhibitor for a variety of cysteine-dependent enzymes.
Journal ArticleDOI
The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor
TL;DR: An efficient synthetic strategy has been developed for the synthesis of a novel fructose conjugated S-nitroso nitric oxide donor, fructose-1-S-Nitroso-N-acetylpenicillamine, which showed similar cytotoxicity as the first generation fructose-SNAP,ructose-2- SNAP.