Yongjia Shang

TL;DR: It is reported that the tumor suppressor protein p53 is downregulated during iron excess, identifying a direct link between iron/heme homeostasis and the regulation of p53 signaling, which provides mechanistic insights into iron-excess-associated tumorigenesis but may also help predict and improve outcomes in iron-deprivation-based chemotherapy.

TL;DR: In this article, tetrakis(4-pyridyloxymethylene)methane (TPOM) with deprotonated 1,4-benzenedicarboxylate (H2BDc) or 5-hydroxyisophthalic acid (5-OH-H2bdc) were characterized by elemental analysis, IR spectroscopy, and X-ray single-crystal diffraction.

TL;DR: In this paper, a 3D framework constructed from 4,4′-bis(imidazol-1-yl)diphenyl ether (BIDPE) with deprotonated 1,4-benzenedicarboxylic acid (H2bdc) in the presence of cadmium, zinc, cobalt, nickel, and manganese salts in H 2O or H2O/DMF yielded six new complexes.

TL;DR: In this article, a concise collective total synthesis of englerinA and B, orientalolE and F, and oxyphyllol has been achieved in 1015 steps.

TL;DR: A mild and efficient Rh(III)-catalyzed C-H activation/esterification reaction for the synthesis of isocoumarins has been developed and provides a facile approach for the construction ofIsocou marins containing various functional groups that does not require any additives.