Y
Yoon Mee Yang
Researcher at Kangwon National University
Publications - 41
Citations - 1426
Yoon Mee Yang is an academic researcher from Kangwon National University. The author has contributed to research in topics: Medicine & Hepatic stellate cell. The author has an hindex of 19, co-authored 33 publications receiving 961 citations. Previous affiliations of Yoon Mee Yang include Cedars-Sinai Medical Center & Seoul National University.
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Journal ArticleDOI
Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets.
TL;DR: The role of cytokine signals, NF-κB, JNK, innate and adaptive immunity, and hepatic stellate cells in HCC are highlighted and whether these pathways could be therapeutic targets are discussed.
Journal ArticleDOI
TNFα in liver fibrosis.
Yoon Mee Yang,Ekihiro Seki +1 more
TL;DR: The role of TNFα in hepatic stellate cell survival and activation, and the crosstalk between hepaticStellate cells and hepatocytes or other immune cells, such as macrophages, dendritic cells, and B cells in the development of liver fibrosis are discussed.
Journal ArticleDOI
Decrease of microRNA‐122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid
TL;DR: Decreased levels of miR‐122 as a consequence of HNF4α phosphorylation by JNK1 lead to hepatic insulin resistance through PTP1B induction, which may be overcome by chemical inhibition of JNK.
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Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis.
Yoon Mee Yang,Yoon Mee Yang,Mazen Noureddin,Cheng Liu,Koichiro Ohashi,So Yeon Kim,Divya Ramnath,Elizabeth E. Powell,Elizabeth E. Powell,Matthew J. Sweet,Yoon Seok Roh,Yoon Seok Roh,I-Fang Hsin,Nan Deng,Zhenqiu Liu,Jiurong Liang,Edward Mena,Daniel Shouhed,Robert F. Schwabe,Dianhua Jiang,Shelly C. Lu,Paul W. Noble,Ekihiro Seki +22 more
TL;DR: Evidence is provided that HAS2 actively synthesizes HA in HSCs and that it promotes HSC activation and liver fibrosis through Notch1 and that Targeted HA inhibition may have potential to be an effective therapy for liver Fibrosis.
Journal ArticleDOI
microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression.
Mi Jeong Heo,Young-Mi Kim,Ja Hyun Koo,Yoon Mee Yang,Jihyun An,Sook-Kyung Lee,Seung Jin Lee,Kang Mo Kim,Joong-Won Park,Sang Geon Kim +9 more
TL;DR: In conclusion, miR-148a dysregulation affects the poor prognosis of HCC, and USP4 overexpression may contribute to HCC progression towards more aggressive feature.