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Yorgo Modis
Researcher at University of Cambridge
Publications - 103
Citations - 9690
Yorgo Modis is an academic researcher from University of Cambridge. The author has contributed to research in topics: Lipid bilayer fusion & MDA5. The author has an hindex of 40, co-authored 97 publications receiving 8363 citations. Previous affiliations of Yorgo Modis include European Bioinformatics Institute & Boston Children's Hospital.
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Journal ArticleDOI
X-ray structure of a protein-conducting channel
Bert van den Berg,William M. Clemons,Ian Collinson,Yorgo Modis,Enno Hartmann,Stephen C. Harrison,Tom A. Rapoport +6 more
TL;DR: The crystal structure of the Sec61 or SecY complex from Methanococcus jannaschii suggests mechanisms for signal-sequence recognition and for the lateral exit of transmembrane segments of nascent membrane proteins into lipid, and indicates binding sites for partners that provide the driving force for translocation.
Journal ArticleDOI
Structure of the dengue virus envelope protein after membrane fusion
TL;DR: This work proposes a fusion mechanism driven by essentially irreversible conformational changes in E and facilitated by fusion-loop insertion into the outer bilayer leaflet, and suggests strategies for inhibiting flavivirus entry.
Journal ArticleDOI
A Ligand-Binding Pocket in the Dengue Virus Envelope Glycoprotein.
TL;DR: A crystal structure of the soluble ectodomain of E from dengue virus type 2 reveals a hydrophobic pocket lined by residues that influence the pH threshold for fusion, which points to a structural pathway for the fusion-activating transition and suggests a strategy for finding small-molecule inhibitors of d Dengue and other flaviviruses.
Journal ArticleDOI
SARS-CoV-2 evolution during treatment of chronic infection.
Steven Kemp,Dami A. Collier,Dami A. Collier,Rawlings Datir,Isabella Ferreira,Salma Gayed,Aminu S Jahun,Myra Hosmillo,Chloe Rees-Spear,Petra Mlcochova,Ines Ushiro Lumb,David J. Roberts,Anita Chandra,Nigel J. Temperton,Katherine Sharrocks,Elizabeth Blane,Yorgo Modis,Yorgo Modis,Kendra E. Leigh,Kendra E. Leigh,John A. G. Briggs,Marit J. van Gils,Kenneth G. C. Smith,John Bradley,Chris Smith,Rainer Doffinger,Lourdes Ceron-Gutierrez,Gabriela Barcenas-Morales,David D. Pollock,Richard A. Goldstein,Anna Smielewska,Jordan P. Skittrall,Theodore Gouliouris,Ian Goodfellow,Effrossyni Gkrania-Klotsas,Christopher J. R. Illingworth,Laura E. McCoy,Ravindra K. Gupta +37 more
TL;DR: In this paper, the authors report chronic SARS-CoV-2 with reduced sensitivity to neutralizing antibodies in an immune suppressed individual treated with convalescent plasma, generating whole genome ultradeep sequences over 23 time points spanning 101 days.
Journal ArticleDOI
SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition
Eunhee Kim,Janine O. Ilagan,Yang Liang,Gerrit M. Daubner,Stanley Chun-Wei Lee,Aravind Ramakrishnan,Aravind Ramakrishnan,Yue Li,Young Rock Chung,Jean Baptiste Micol,Michele E. Murphy,Hana Cho,Min Kyung Kim,Ahmad S. Zebari,Shlomzion Aumann,Christopher Y. Park,Silvia Buonamici,Pete Smith,H. Joachim Deeg,H. Joachim Deeg,Camille Lobry,Camille Lobry,Iannis Aifantis,Yorgo Modis,Yorgo Modis,Frédéric H.-T. Allain,Stephanie Halene,Robert K. Bradley,Omar Abdel-Wahab +28 more
TL;DR: It is reported that mutations affecting the splicing factor S RSF2 directly impair hematopoietic differentiation in vivo, which is not due to SRSF2 loss of function, and this data provide a mechanistic link between a mutant spliceosomal protein, alterations in thesplicing of key regulators, and impaired hematoiesis.