Yoshiaki Hasegawa

TL;DR: P. gingivalis, an opportunistic pathogen in periodontal disease, can reside within the epithelial cells that line theGingival crevice and induces broadly based changes in the level and phosphorylation status of proteins that exert multi-level control on the eukaryotic cell cycle.

TL;DR: The biological pathways significantly impacted by F. nucleatum and S. gordonii included the mitogen-activated protein kinase (MAPK) and Toll-like receptor signaling pathways and differential regulation of GADD45 and DUSP4, key components of the MAPK pathway, was confirmed at the protein level by Western blotting.

TL;DR: This minireview focused on recent research findings concerning surface components such as outer membrane proteins and fimbriae, of P. gingivalis, a periodontopathogen, which somehow have contact with host tissues and cells because of the outermost cell elements.

TL;DR: Results strongly suggest that this newly‐discovered two‐component sensor kinase is involved in maturation and proper localization of gingipains to the outer membrane through an unknown mechanism.

TL;DR: Co-immunoprecipitation demonstrated that Mfa2 and Mfa1 are associated with each other in whole P. gingivalis cells, and immunogold microscopy confirmed that MFA2 was located on the cell surface and likely associated with Mfa 1 fimbriae.