Yoshiaki Kido

TL;DR: It is proposed that insulin/IGFs regulate beta cell proliferation by relieving Foxo1 inhibition of Pdx1 expression in a subset of cells embedded within pancreatic ducts.

TL;DR: Evidence from genetically engineered mice does not support the view that insulin and IGF receptors promote cellular differentiation in vivo or that they are required for early embryonic development, and the phenotypes of insulin receptor gene mutations in humans and in mice indicate important differences between the developmental roles of insulin and its receptor in the two species.

TL;DR: Tissue-specific differences in the roles of IRSs to mediate insulin action are indicated, with irs-1 playing a prominent role in skeletal muscle and irS-2 in liver and ir/irs-2(+/-) mice developing severe insulin resistance in liver, with compensatory beta-cell hyperplasia.

TL;DR: Liver-specific expression of a constitutively active form of STAT-3, achieved by infection with an adenovirus vector, markedly reduced blood glucose, plasma insulin concentrations and hepatic gluconeogenic gene expression in diabetic mice.

TL;DR: The presence of multiple insulin-regulated, PIP3-dependent kinases is consistent with the possibility that different pathways are required to regulate different biological actions of insulin.