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Yoshihiko Yano
Researcher at Kobe University
Publications - 142
Citations - 1612
Yoshihiko Yano is an academic researcher from Kobe University. The author has contributed to research in topics: Hepatitis B virus & Hepatocellular carcinoma. The author has an hindex of 18, co-authored 129 publications receiving 1380 citations.
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Journal ArticleDOI
The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity
Jun Nakae,Yongheng Cao,Hiroaki Daitoku,Akiyoshi Fukamizu,Wataru Ogawa,Yoshihiko Yano,Yoshitake Hayashi +6 more
TL;DR: The LXXLL motif of FoxO1 may have an important role for its transcriptional activity and Sirt1 binding and should be a target site for regulation of gene expression ofFoxO1 target genes and glucose metabolism in vivo.
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Nonalcoholic fatty liver disease in adult hypopituitary patients with GH deficiency and the impact of GH replacement therapy.
Hitoshi Nishizawa,Genzo Iguchi,Ayumi Murawaki,Hidenori Fukuoka,Yoshitake Hayashi,Hidesuke Kaji,Masaaki Yamamoto,Kentaro Suda,Michiko Takahashi,Yasushi Seo,Yoshihiko Yano,Riko Kitazawa,Sohei Kitazawa,Masafumi Koga,Yasuhiko Okimura,Kazuo Chihara,Yutaka Takahashi +16 more
TL;DR: The effect of GH replacement therapy suggests that the NAFLD is predominantly attributable to GHD, and adult hypopituitary patients with GHD demonstrated a highNAFLD prevalence.
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Activation of the aryl hydrocarbon receptor induces hepatic steatosis via the upregulation of fatty acid transport.
Yuki Kawano,Shin Nishiumi,Shinwa Tanaka,Kentaro Nobutani,Akira Miki,Yoshihiko Yano,Yasushi Seo,Hiromu Kutsumi,Hitoshi Ashida,Takeshi Azuma,Masaru Yoshida +10 more
TL;DR: AHR activation induces hepatic microvesicular steatosis by increasing the expression level of FAT and the mRNA level of peroxisome proliferator-activated receptor (PPAR) α was increased in the livers of 3MC-treated mice.
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Perfusion measurement of the whole upper abdomen of patients with and without liver diseases: initial experience with 320-detector row CT.
Tomonori Kanda,Takeshi Yoshikawa,Yoshiharu Ohno,Yasuko Fujisawa,Naoki Kanata,Masato Yamaguchi,Yasushi Seo,Yoshihiko Yano,Hisanobu Koyama,Kazuhiro Kitajima,Daisuke Takenaka,Kazuro Sugimura +11 more
TL;DR: The preliminary results suggested that estimated perfusion values have the potential to be used for evaluation of hepatic diseases and therapeutic effects.
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IFN-alpha prevents the growth of pre-neoplastic lesions and inhibits the development of hepatocellular carcinoma in the rat
Miyuki Nakaji,Yoshihiko Yano,Toshiaki Ninomiya,Yasushi Seo,Kenichi Hamano,Seitetsu Yoon,Masato Kasuga,Tadahisa Teramoto,Yoshitake Hayashi,Hiroshi Yokozaki +9 more
TL;DR: It was shown that IFN-alpha directly prevented and delayed hepatocarcinogenesis through the suppression of pre-neoplastic cell proliferation and that it may partially depend on p21 induction through a p53-independent pathway.