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Author

Yoshimasa Hirata

Other affiliations: Nagoya University
Bio: Yoshimasa Hirata is an academic researcher from Meijo University. The author has contributed to research in topics: Palytoxin & Daphniphyllum. The author has an hindex of 41, co-authored 201 publications receiving 4935 citations. Previous affiliations of Yoshimasa Hirata include Nagoya University.


Papers
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Journal ArticleDOI
TL;DR: The results indicate that delta 12-PGJ2 is formed naturally in the body and excreted as a urinary PGD2 metabolite.

145 citations

Journal ArticleDOI
TL;DR: Keramamine-A and -B, two β-carboline alkaloids with a 13 membered ring have been isolated from the Okinawan marine sponge Pellina sp. as mentioned in this paper.

131 citations


Cited by
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Journal ArticleDOI
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.

4,649 citations

Journal ArticleDOI
01 Dec 1995-Cell
TL;DR: A pivotal role is suggested for PPARγ and its endogenous ligand in adipocyte development and glucose homeostasis and as a target for intervention in metabolic disorders.

2,809 citations

Journal ArticleDOI
TL;DR: Alkylations with Phenols, Nitrogen Nucleophiles in AAA Total Synthesis, and Considerations for Enantioselective Allylic Alkylation are presented.
Abstract: A. Primary Alcohols as Nucleophiles 2931 B. Carboxylates as Nucleophiles 2931 C. Alkylations with Phenols 2932 IV. Nitrogen Nucleophiles in AAA Total Synthesis 2935 A. Alkylamines as Nucleophiles 2935 B. Azides as a Nucleophile 2936 C. Sulfonamide Nucleophiles 2937 D. Imide Nucleophiles 2938 E. Heterocyclic Amine Nucleophiles 2940 V. Sulfur Nucleophiles 2941 VI. Summary and Conclusions 2941 VII. Acknowledgment 2941 VIII. References 2942 I. Considerations for Enantioselective Allylic Alkylation

2,230 citations

Journal ArticleDOI
01 Dec 1995-Cell
TL;DR: The PGJ2 and its derivatives are efficacious activators of peroxisome proliferator-activated receptors alpha and gamma (PPAR alpha and PPAR gamma, respectively), orphan nuclear receptors implicated in lipid homeostasis and adipocyte differentiation and suggest a novel mechanism of action for PGs of the J2 series.

2,081 citations

Journal ArticleDOI
TL;DR: The power of cascade reactions in total synthesis is illustrated in the construction of complex molecules and underscore their future potential in chemical synthesis.
Abstract: The design and implementation of cascade reactions is a challenging facet of organic chemistry, yet one that can impart striking novelty, elegance, and efficiency to synthetic strategies. The application of cascade reactions to natural products synthesis represents a particularly demanding task, but the results can be both stunning and instructive. This Review highlights selected examples of cascade reactions in total synthesis, with particular emphasis on recent applications therein. The examples discussed herein illustrate the power of these processes in the construction of complex molecules and underscore their future potential in chemical synthesis.

1,762 citations