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Yoshinori Ohsumi
Researcher at Tokyo Institute of Technology
Publications - 272
Citations - 72517
Yoshinori Ohsumi is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Autophagy & Vacuole. The author has an hindex of 109, co-authored 267 publications receiving 66470 citations. Previous affiliations of Yoshinori Ohsumi include University of Shizuoka & Kogakuin University.
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Journal ArticleDOI
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
Yukiko Kabeya,Noboru Mizushima,Noboru Mizushima,Takashi Ueno,Akitsugu Yamamoto,Takayoshi Kirisako,Takayoshi Kirisako,Takeshi Noda,Takeshi Noda,Eiki Kominami,Yoshinori Ohsumi,Yoshinori Ohsumi,Tamotsu Yoshimori,Tamotsu Yoshimori +13 more
TL;DR: It is demonstrated that the rat microtubule‐associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is associated to the autophagosome membranes after processing.
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The role of autophagy during the early neonatal starvation period
Akiko Kuma,Masahiko Hatano,Makoto Matsui,Makoto Matsui,Akitsugu Yamamoto,Haruaki Nakaya,Tamotsu Yoshimori,Yoshinori Ohsumi,Takeshi Tokuhisa,Noboru Mizushima,Noboru Mizushima,Noboru Mizushima +11 more
TL;DR: The results suggest that the production of amino acids by autophagic degradation of ‘self’ proteins, which allows for the maintenance of energy homeostasis, is important for survival during neonatal starvation.
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The Role of Atg Proteins in Autophagosome Formation
TL;DR: The molecular mechanism of autophagosome formation is described with particular focus on the function of Atg proteins and the long-standing discussion regarding the origin of the autophagous membrane membrane.
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Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
Masaaki Komatsu,Satoshi Waguri,Takashi Ueno,Junichi Iwata,Shigeo Murata,Isei Tanida,Junji Ezaki,Noboru Mizushima,Yoshinori Ohsumi,Yasuo Uchiyama,Eiki Kominami,Keiji Tanaka,Tomoki Chiba +12 more
TL;DR: Conditional knockout mice of Atg7 were generated and showed the important role of autophagy in starvation response and the quality control of proteins and organelles in quiescent cells.
Journal ArticleDOI
In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker
Noboru Mizushima,Akitsugu Yamamoto,Makoto Matsui,Makoto Matsui,Tamotsu Yoshimori,Yoshinori Ohsumi,Yoshinori Ohsumi +6 more
TL;DR: The results suggest that the regulation of autophagy is organ dependent and the role of Aut7/Apg8 is not restricted to the starvation response, and this transgenic mouse model is a useful tool to study mammalian autophagic regulation.