Y
Yoshiya Kawaguchi
Researcher at Kyoto University
Publications - 114
Citations - 11701
Yoshiya Kawaguchi is an academic researcher from Kyoto University. The author has contributed to research in topics: Pancreas & Pancreatic cancer. The author has an hindex of 41, co-authored 110 publications receiving 10710 citations. Previous affiliations of Yoshiya Kawaguchi include National Presto Industries & Vanderbilt University.
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Journal ArticleDOI
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Sunil R. Hingorani,Emanuel F. Petricoin,Anirban Maitra,Vinodh N. Rajapakse,Catrina King,Michael A. Jacobetz,Sally Ross,Thomas P. Conrads,Timothy D. Veenstra,Ben A. Hitt,Yoshiya Kawaguchi,Donald J. Johann,Lance A. Liotta,Howard C. Crawford,Mary E. Putt,Tyler Jacks,Christopher V.E. Wright,Ralph H. Hruban,Andrew M. Lowy,David A. Tuveson +19 more
TL;DR: It is found that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer.
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CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1
Yoshiya Kawaguchi,Toshihiro Okamoto,Masafumi Taniwaki,Megumi Aizawa,Miho Inoue,Sadao Katayama,Hideshi Kawakami,Shigenobu Nakamura,Masaki Nishimura,Ichiro Akiguchi,Jun Kimura,Shuh Narumiya,Akira Kakizuka +12 more
TL;DR: Southern blot analyses and genomic cloning demonstrates the existence of related genes, raising the possibility that similar abnormalities in related genes may give rise to diseases similar to Machado-Joseph disease.
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The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
Yoshiya Kawaguchi,Bonnie Cooper,Maureen Gannon,Michael Ray,Raymond J. MacDonald,Christopher V.E. Wright +5 more
TL;DR: Rec recombination-based lineage tracing in vivo is used to show that PTF1a is expressed at these early stages in the progenitors of pancreatic ducts, exocrine and endocrine cells, rather than being an exocrine-specific gene as previously described.
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Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
Kenichiro Furuyama,Yoshiya Kawaguchi,Haruhiko Akiyama,Masashi Horiguchi,S. Kodama,T. Kuhara,Shinichi Hosokawa,Ashraf Elbahrawy,Tsunemitsu Soeda,Masayuki Koizumi,Toshihiko Masui,Michiya Kawaguchi,Kyoichi Takaori,Ryuichiro Doi,Eiichiro Nishi,Ryosuke Kakinoki,Jian Min Deng,Richard R. Behringer,Takashi Nakamura,Shinji Uemoto +19 more
TL;DR: It is shown that Sox9 is expressed throughout the biliary and pancreatic ductal epithelia, which are connected to the intestinal stem-cell zone, which suggests interdependence between the structure and homeostasis of endodermal organs, with Sox9 expression being linked to progenitor status.
Journal ArticleDOI
Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum.
Mikio Hoshino,Shoko Nakamura,Kiyoshi Mori,Kiyoshi Mori,Takeshi Kawauchi,Mami Terao,Yoshiaki V. Nishimura,Akihisa Fukuda,Toshimitsu Fuse,Naoki Matsuo,Masaki Sone,Masaki Sone,Masahiko Watanabe,Haruhiko Bito,Toshio Terashima,Christopher V.E. Wright,Yoshiya Kawaguchi,Yoshiya Kawaguchi,Kazuwa Nakao,Yo-ichi Nabeshima +19 more
TL;DR: A Cerebellar mutant, cerebelless, is described, which lacks the entire cerebellar cortex in adults and results suggest that Ptf1a is involved in driving neural precursors to differentiate into GABAergic neurons in the cerebellum.