scispace - formally typeset
Search or ask a question
Author

Yosuke Tanaka

Bio: Yosuke Tanaka is an academic researcher from Tokyo University of Agriculture and Technology. The author has contributed to research in topics: Optical fiber & Interferometry. The author has an hindex of 26, co-authored 239 publications receiving 2509 citations. Previous affiliations of Yosuke Tanaka include Dr Emilio B Espinosa Sr Memorial State College of Agriculture and Technology & University of Tokyo.


Papers
More filters
Journal ArticleDOI
TL;DR: It is concluded that mitochondrial dysfunction and subsequent activation of the mtDNA-cGAS-STING pathway is a critical regulator of kidney injury.

241 citations

Journal ArticleDOI
01 Mar 1997-Blood
TL;DR: The possibility that these two cytokines, interleukin-10 and IL-4, may both offer potent clinical utility as anti-inflammatory agents in the future is raised.

169 citations

Journal ArticleDOI
22 Dec 2011-Blood
TL;DR: Etv2 is dispensable for generating primitive Flk-1(+)/PDGFRα(+) mesoderm but is required for the progression of Flk/hematopoietic stem cell-generating cells into vascular/hematoplastic mesodern through Etv2 and up-regulation of ETV2 by VEGF promotes this commitment.

162 citations

Journal ArticleDOI
TL;DR: With this prophylaxis, the cumulative incidence of VZV reactivation at 1 year after transplantation decreased from 33% to 10% and the use of long-term acyclovir was identified as a significant independent parameter for the development of V zoster virus reactivation.
Abstract: To evaluate the efficacy of long-term administration of acyclovir as prophylaxis against varicella-zoster virus (VZV) reactivation, we analyzed the medical records of 86 consecutive adult patients who obtained engraftment after allogeneic hematopoietic stem cell transplantation from January 1996 to March 2000. We started long-term low-dose (400 mg/day) oral administration of acyclovir in June 1999, and this was continued until the end of immunosuppressive therapy after transplantation. There was no breakthrough reactivation of VZV in patients receiving acyclovir. Five patients who were receiving cyclosporine or prednisolone developed VZV reactivation after discontinuing acyclovir. With this prophylaxis, the cumulative incidence of VZV reactivation at 1 year after transplantation decreased from 33% to 10% (P = 0.025). On multivariate analysis, the use of long-term acyclovir was identified as a significant independent parameter for the development of VZV reactivation. These findings suggest the efficacy of long-term prophylaxis with low-dose acyclovir. Resumption of acyclovir upon restarting immunosuppressive therapy might be important for the further prevention of VZV reactivation. The benefit of long-term low-dose acyclovir should be confirmed prospectively.

102 citations

Proceedings ArticleDOI
TL;DR: IRD as mentioned in this paper is the near-infrared high-precision radial velocity instrument for the Subaru 8.2-m telescope, which employs a 4096x4096-pixel HgCdTe array under testing at IfA, University of Hawaii.
Abstract: IRD is the near-infrared high-precision radial velocity instrument for the Subaru 8.2-m telescope. It is a relatively compact (~1m size) spectrometer with a new echelle-grating and Volume-Phase Holographic gratings covering 1-2 micron wavelengths combined with an original frequency comb using optical pulse synthesizer. The spectrometer will employ a 4096x4096-pixel HgCdTe array under testing at IfA, University of Hawaii. Both the telescope/Adaptive Optics and comb beams are fed to the spectrometer via optical fibers, while the instrument is placed at the Nasmyth platform of the Subaru telescope. Expected accuracy of the Doppler-shifted velocity measurements is about 1 m s-1. Helped with the large collecting area and high image quality of the Subaru telescope, IRD can conduct systematic radial velocity surveys of nearby middle-to-late M stars aiming for down to one Earth-mass planet. Systematic observational and theoretical studies of M stars and their planets for the IRD science are also ongoing. We will report the design and preliminary development progresses of the whole and each component of IRD.

86 citations


Cited by
More filters
Journal ArticleDOI
TL;DR: Findings that have advanced the understanding of IL-10 and its receptor are highlighted, as well as its in vivo function in health and disease.
Abstract: Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on most hemopoietic cell types. The principal routine function of IL-10 appears to be to limit and ultimately terminate inflammatory responses. In addition to these activities, IL-10 regulates growth and/or differentiation of B cells, NK cells, cytotoxic and helper T cells, mast cells, granulocytes, dendritic cells, keratinocytes, and endothelial cells. IL-10 plays a key role in differentiation and function of a newly appreciated type of T cell, the T regulatory cell, which may figure prominently in control of immune responses and tolerance in vivo. Uniquely among hemopoietic cytokines, IL-10 has closely related homologs in several virus genomes, which testify to its crucial role in regulating immune and inflammatory responses. This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease.

6,308 citations

Journal Article
TL;DR: In this article, a fast Fourier transform method of topography and interferometry is proposed to discriminate between elevation and depression of the object or wave-front form, which has not been possible by the fringe-contour generation techniques.
Abstract: A fast-Fourier-transform method of topography and interferometry is proposed. By computer processing of a noncontour type of fringe pattern, automatic discrimination is achieved between elevation and depression of the object or wave-front form, which has not been possible by the fringe-contour-generation techniques. The method has advantages over moire topography and conventional fringe-contour interferometry in both accuracy and sensitivity. Unlike fringe-scanning techniques, the method is easy to apply because it uses no moving components.

3,742 citations

Journal ArticleDOI
TL;DR: The Transiting Exoplanet Survey Satellite (TESS) as discussed by the authors will search for planets transiting bright and nearby stars using four wide-field optical charge-coupled device cameras to monitor at least 200,000 main-sequence dwarf stars.
Abstract: The Transiting Exoplanet Survey Satellite (TESS) will search for planets transiting bright and nearby stars. TESS has been selected by NASA for launch in 2017 as an Astrophysics Explorer mission. The spacecraft will be placed into a highly elliptical 13.7-day orbit around the Earth. During its 2-year mission, TESS will employ four wide-field optical charge-coupled device cameras to monitor at least 200,000 main-sequence dwarf stars with I C ≈4−13 for temporary drops in brightness caused by planetary transits. Each star will be observed for an interval ranging from 1 month to 1 year, depending mainly on the star’s ecliptic latitude. The longest observing intervals will be for stars near the ecliptic poles, which are the optimal locations for follow-up observations with the James Webb Space Telescope. Brightness measurements of preselected target stars will be recorded every 2 min, and full frame images will be recorded every 30 min. TESS stars will be 10 to 100 times brighter than those surveyed by the pioneering Kepler mission. This will make TESS planets easier to characterize with follow-up observations. TESS is expected to find more than a thousand planets smaller than Neptune, including dozens that are comparable in size to the Earth. Public data releases will occur every 4 months, inviting immediate community-wide efforts to study the new planets. The TESS legacy will be a catalog of the nearest and brightest stars hosting transiting planets, which will endure as highly favorable targets for detailed investigations.

2,604 citations

Journal ArticleDOI
15 Oct 2005-Blood
TL;DR: The new simple index provided valid and reliable scoring of pretransplant comorbidities that predicted nonrelapse mortality and survival and will be useful for clinical trials and patient counseling before HCT.

2,193 citations

01 Jan 2011
TL;DR: The sheer volume and scope of data posed by this flood of data pose a significant challenge to the development of efficient and intuitive visualization tools able to scale to very large data sets and to flexibly integrate multiple data types, including clinical data.
Abstract: Rapid improvements in sequencing and array-based platforms are resulting in a flood of diverse genome-wide data, including data from exome and whole-genome sequencing, epigenetic surveys, expression profiling of coding and noncoding RNAs, single nucleotide polymorphism (SNP) and copy number profiling, and functional assays. Analysis of these large, diverse data sets holds the promise of a more comprehensive understanding of the genome and its relation to human disease. Experienced and knowledgeable human review is an essential component of this process, complementing computational approaches. This calls for efficient and intuitive visualization tools able to scale to very large data sets and to flexibly integrate multiple data types, including clinical data. However, the sheer volume and scope of data pose a significant challenge to the development of such tools.

2,187 citations