CA : A Cancer Journal for Clinicians

Objective To address terminology and other issues related to thyroid fine-needle aspiration (FNA), the National Cancer Institute (NCI) hosted The NCI Thyroid FNA State of the Science Conference. The conclusions regarding terminology and morphologic criteria from the NCI meeting led to the Bethesda Thyroid Atlas Project and form the framework for the Bethesda System for Reporting Thyroid Cytopathology. Design Participants of the Atlas Project were selected from among the committee members of the NCI FNA State of the Science Conference and other participants at the live conference. The terminology framework was based on a literature search of English language publications dating back to 1995 using PubMed as the search engine; online forum discussions ( http://thyroidfna.cancer.gov/forums/default.aspx ); and formal interdisciplinary discussions held on October 22 and 23, 2007, in Bethesda, MD. Main outcome For clarity of communication, the Bethesda System for Reporting Thyroid Cytopathology recommends that each report begin with one of the six general diagnostic categories. Each of the categories has an implied cancer risk that links it to an appropriate clinical management guideline. Conclusions The project participants hope that the adoption of this framework will facilitate communication among cytopathologists, endocrinologists, surgeons, and radiologists; facilitate cytologic-histologic correlation for thyroid diseases; facilitate research into the understanding of thyroid diseases; and allow easy and reliable sharing of data from different laboratories for national and international collaborative studies.

The Bethesda System for Reporting Thyroid Cytopathology.

Summary Background Compared with open resection, laparoscopic resection of rectal cancers is associated with improved short-term outcomes, but high-level evidence showing similar long-term outcomes is scarce. We aimed to compare survival outcomes of laparoscopic surgery with open surgery for patients with mid-rectal or low-rectal cancer. Methods The Comparison of Open versus laparoscopic surgery for mid or low REctal cancer After Neoadjuvant chemoradiotherapy (COREAN) trial was an open-label, non-inferiority, randomised controlled trial done between April 4, 2006, and Aug 26, 2009, at three centres in Korea. Patients (aged 18–80 years) with cT3N0–2M0 mid-rectal or low-rectal cancer who had received preoperative chemoradiotherapy were randomly assigned (1:1) to receive either open or laparoscopic surgery. Randomisation was stratified by sex and preoperative chemotherapy regimen. Investigators were masked to the randomisation sequence; patients and clinicians were not masked to the treatment assignments. The primary endpoint was 3 year disease-free survival, with a non-inferiority margin of 15%. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00470951. Findings We randomly assigned 340 patients to receive either open surgery (n=170) or laparoscopic surgery (n=170). 3 year disease-free survival was 72·5% (95% CI 65·0–78·6) for the open surgery group and 79·2% (72·3–84·6) for the laparoscopic surgery group, with a difference that was lower than the prespecified non-inferiority margin (–6·7%, 95% CI −15·8 to 2·4; p Interpretation Our results show that laparoscopic resection for locally advanced rectal cancer after preoperative chemoradiotherapy provides similar outcomes for disease-free survival as open resection, thus justifying its use. Funding National Cancer Center, South Korea.

https://www.thelancet.com/pdfs/journals/lanonc/PIIS1470-2045(14)70205-0.pdf

Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial.

Objective:To determine the safety of laparoscopy-assisted distal gastrectomy (LADG) compared with open distal gastrectomy (ODG) in patients with clinical stage I gastric cancer in Korea.Background:There is still a lack of large-scale, multicenter randomized trials regarding the safety of LADG.Method

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Decreased Morbidity of Laparoscopic Distal Gastrectomy Compared With Open Distal Gastrectomy for Stage I Gastric Cancer: Short-term Outcomes From a Multicenter Randomized Controlled Trial (KLASS-01).

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The Foundations Of Differential Geometry

In this paper, we introduce the notion of recurrent conformal 2-forms on a pseudo-Riemannian manifold of arbitrary signature. Some theorems already proved for the same differential structure on a Riemannian manifold are proven to hold in this more general contest. Moreover other interesting results are pointed out; it is proven that if the associated covector is closed, then the Ricci tensor is Riemann compatible or equivalently, Weyl compatible: these notions were recently introduced and investigated by one of the present authors. Further some new results about the vanishing of some Weyl scalars on a pseudo-Riemannian manifold are given: it turns out that they are consequence of the generalized Derdzinski–Shen theorem. Topological properties involving the vanishing of Pontryagin forms and recurrent conformal 2-forms are then stated. Finally, we study the properties of recurrent conformal 2-forms on Lorentzian manifolds (space-times). Previous theorems stated on a pseudo-Riemannian manifold of arbitrary signature are then interpreted in the light of the classification of space-times in four or in higher dimensions.

Recurrent conformal 2-forms on pseudo-Riemannian manifolds

http://webbuild.knu.ac.kr/~yjsuh/Publications/2004/[2004]4%20Baek,%20Cheng,%20Suh.pdf

Complete space-like hypersurfaces in locally symmetric Lorentz spaces

In this paper we give a characterization of real hypersurfaces of type A in a complex two- plane Grassmannian G2(C m+2 ) which are tubes over totally geodesic G2(C m+1 ) in G2(C m+2 ) in terms of the vanishing Lie derivative of the shape operator A along the direction of the Reeb vector field �.

http://webbuild.knu.ac.kr/~yjsuh/Publications/2006/%5B2006%5D6%20Suh.pdf

Real Hypersurfaces in Complex Two-Plane Grassmannians with Vanishing Lie Derivative

We study real hypersurfaces of a complex space form Mn(c). The purpose is to give another characterization of pseudo-Einstein hypersurfaces and then to prove that there are no real hypersurfaces with harmonic Weyl tensor of Mn(c\ c ^ 0, n > 3.

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Real hypersurfaces with harmonic Weyl tensor of a complex space form

In this paper we give a non-existence property of real hypersurfaces in complex two-plane Grassmannians G2(ℂm+2) which have a shape operator A commuting with the structure tensors {φ1, φ2, φ3} From this view point we give a characterisation of real hypersurfaces of type B in G2(ℂm+2)

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Young Jin Suh

Papers

Recurrent conformal 2-forms on pseudo-Riemannian manifolds

Complete space-like hypersurfaces in locally symmetric Lorentz spaces

Real Hypersurfaces in Complex Two-Plane Grassmannians with Vanishing Lie Derivative

Real hypersurfaces with harmonic Weyl tensor of a complex space form

Real hypersurfaces in complex two-plane Grassmannians with commuting shape operator