Young Suk Choi

TL;DR: The biocompatibility of the chitosan nanofiber membrane was confirmed, with enhanced bone regeneration and no evidence of an inflammatory reaction, and shows that the novel biodegradable chitOSan nan ofiber membrane may be useful as a tool for guided bone regeneration.

TL;DR: The authors describe a peptide/siRNA complex containing the cell penetrating peptide derived from natural protamine, termed low molecular weight protamine (LMWP), for the treatment of cancer and demonstrate that the peptide could carry and localize siRNA inside tumors and inhibit the expression of VEGF through systemic application of the peptides, thereby suppressing tumor growth.

TL;DR: The goal was to evaluate the delivery of miRNA, i.e., miRNA-29b, to stem cells to promote osteoblastic differentiation because this miRNA is known to target anti-osteogenic factors gene expression and synthetic double-stranded miR- 29b could be induced osteoblast differentiation.

TL;DR: It is demonstrated that the CBM peptide in complex with material was able to induce bone formation by helping mineralization in the bone defect and can be applied as an inducer of biomineralization as well as a bioactive scaffold for bone regeneration.

TL;DR: Results revealed that self-assembled OPDA maintained osteogenic activity by the surface-exposed OPD peptide, and can be utilized as a cell culture scaffold in bone regeneration.