scispace - formally typeset
Search or ask a question

Showing papers by "Yu Huang published in 1990"


Journal ArticleDOI
19 Apr 1990-Nature
TL;DR: It is reported that arterial dilations in response to CGRP are partially reversed by blockers of the ATP-sensitive potassium channel (KATP), glibenclamide10–12 and barium10,13 and proposed that activation of KATP channels underlies a substantial part of the relaxation produced by C GRP.
Abstract: Calcitonin gene-related peptide (CGRP) is a 37-amino-acid peptide produced by alternative processing of messenger RNA from the calcitonin gene. CGRP is one of the most potent vasodilators known. It occurs in and is released from perivascular nerves and has been detected in the blood stream, suggesting that it is important in the control of blood flow. The mechanism by which it dilates arteries is not known. Here, we report that arterial dilations in response to CGRP are partially reversed by blockers of the ATP-sensitive potassium channel (K(ATP)), glibenclamide and barium. We also show that CGRP hyperpolarizes arterial smooth muscle and that blockers of K(ATP) channels reverse this hyperpolarization. Finally, we show that CGRP opens single K+ channels in patches on single smooth muscle cells from the same arteries. We propose that activation of K(ATP) channels underlies a substantial part of the relaxation produced by CGRP.

465 citations


Journal ArticleDOI
TL;DR: In this paper, the effect of fast neutron irradiation with doses from 1×1012 to 1×1016 n/cm2 was studied and it was observed that peak and valley positions shifted to higher voltages, and peak-to-valley ratios decreased with higher doses in static currentvoltage characteristics.
Abstract: Resonant tunneling by fast neutron irradiation with doses from 1×1012 to 1×1016 n/cm2 was studied. We observed that peak and valley positions shifted to higher voltages, and peak‐to‐valley ratios decreased with higher doses in static current‐voltage characteristics. Several models which take into account ionized impurities were used to give consistent explanation to such phenomena.

11 citations