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Author

Yu Huang

Bio: Yu Huang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Materials science. The author has an hindex of 136, co-authored 1492 publications receiving 89209 citations. Previous affiliations of Yu Huang include The Chinese University of Hong Kong & Samsung.


Papers
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Journal ArticleDOI
TL;DR: Investigating how gut microbiota shapes metabolic signatures in multiple brain regions of schizophrenia microbiota recipient mice suggests alterations of glycerophospholipid and fatty acyl metabolism are implicated in the onset of schizophrenia-relevant behaviors, which may provide a new understanding of the etiology of schizophrenia.
Abstract: Background Schizophrenia is a debilitating psychiatric disorder characterized by molecular and anatomical abnormalities of multiple brain regions. Our recent study showed that dysbiosis of the gut microbiota contributes to the onset of schizophrenia-relevant behaviors, but the underlying mechanisms remain largely unknown. Purpose This study aimed to investigate how gut microbiota shapes metabolic signatures in multiple brain regions of schizophrenia microbiota recipient mice. Methods Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) were used to compare the metabolic signatures in the cortex, cerebellum and striatum of schizophrenia microbiota and healthy microbiota recipient mice. Enrichment analysis was further conducted to uncover the crucial metabolic pathways related to schizophrenia-relevant behaviors. Results We found that the metabolic phenotypes of these three regions were substantially different in schizophrenia microbiota recipient mice from those in healthy microbiota recipient mice. In total, we identified 499 differential metabolites that could discriminate the two groups in the three brain regions. These differential metabolites were mainly involved in glycerophospholipid and fatty acyl metabolism. Moreover, we found four of fatty acyl metabolites that were consistently altered in the three brain regions. Conclusion Taken together, our study suggests that alterations of glycerophospholipid and fatty acyl metabolism are implicated in the onset of schizophrenia-relevant behaviors, which may provide a new understanding of the etiology of schizophrenia.

20 citations

Journal ArticleDOI
TL;DR: LINC00473 might be involved in HCC progression by acting as a miR-29a-3p sponge to upregulate the expression of Robo1 that activates the PI3K/AKT/mTOR signaling pathway, which leads to enhanced cell proliferation, migration, invasion, tumor progression, and metastasis in H CC.
Abstract: Background:Long non-coding RNAs have suppressive or oncogenic effects in various types of cancers by serving as competing endogenous RNAs for specific microRNAs. In the present study, we aim to del...

20 citations

Proceedings ArticleDOI
Fei Wang1, Yu Hu1, Huawei Li1, Xiaowei Li1, Jing Ye1, Yu Huang2 
08 Dec 2008
TL;DR: Experimental results show that the diagnostic resolution and precision are not degraded even with dozens of faults injected into the system logic.
Abstract: Scan chain failure diagnosis has become an important means for silicon debug and yield improvement. Although plenty of prior work discussed how to perform scan chain diagnosis, most of the previously proposed techniques made an assumption that the system logic is fault-free, which could be an impractical assumption leading to incorrect diagnostic results. In this paper, we propose a scan chain deterministic diagnostic pattern generation (DDPG) method that can tolerate the faults in the system logic without degradation of chain diagnostic resolution and precision. The entire flow includes three steps. In the first step, patterns are created to propagate the state of a targeted scan cell to as many reliable observation points as possible. In the second step, the load error probability of each targeted scan cell is calculated based on the hamming distances between the observed responses and the expected good or faulty responses. In the last step, a suspect profile is plotted, which can be used to identify the suspect scan cell(s) based on ranking scores. Experimental results show that the diagnostic resolution and precision are not degraded even with dozens of faults injected into the system logic.

20 citations

Journal ArticleDOI
TL;DR: It is demonstrated that not only soybean seeds but also soy leaves are cardioprotective, by favorably modulating serum lipid profile.
Abstract: The present study was to examine effect of soy leaf powder (SLP) and soy leaf ethanol extract (SLEE) on serum lipoproteins in hamsters. The control group was fed a semisynthetic diet containing 0.1% cholesterol, while the tested groups were maintained on the same diet but supplemented with 3% SLP or the equivalent amount of SLEE derived from 3% SLP for 4 weeks. SLP supplementation led to a trend of lowering serum total cholesterol (TC) and nonhigh density lipoprotein cholesterol (non-HDL-C), with HDL-C being unaffected, whereas incorporation of SLEE into the diet led to an elevated level of HDL-C and a lower level of non-HDL-C with TC being unchanged. Both SLP and SLEE supplementation caused favorably a decrease in the ratio of non-HDL-C to HDL-C. The present results demonstrate that not only soybean seeds but also soy leaves are cardioprotective, by favorably modulating serum lipid profile.

20 citations

Proceedings ArticleDOI
01 Dec 2008
TL;DR: A layered method to resolve the visibility problem in depth image-based rendering using a novel three-layer representation for each reference view, i.e. the main layer, background layer and the boundary layer, is proposed.
Abstract: A layered method is presented in this paper to resolve the visibility problem in depth image-based rendering. A novel three-layer representation for each reference view, i.e. the main layer, background layer and the boundary layer, is proposed. A spatial-temporal method is designed to generate the boundary layer for pixel-based rendering (splatting). Meanwhile, a temporal background model is built for each frame by searching backward and forward for uncovered background information based on depth variance in the reference video. Promising results of view synthesis using the multiple-view 3d data from Microsoft Research, ldquobreak dancerrdquo and ldquoballetrdquo, are given to demonstrate the performance of the proposed method.

20 citations


Cited by
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08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

01 May 1993
TL;DR: Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems.
Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

29,323 citations

28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

18,940 citations