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Yu Huang

Bio: Yu Huang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Materials science. The author has an hindex of 136, co-authored 1492 publications receiving 89209 citations. Previous affiliations of Yu Huang include The Chinese University of Hong Kong & Samsung.


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TL;DR: In this article, the authors investigated the effect of living sulfate-reducing bacteria (SRB) on hydrogen permeation in the sea mud with and without SRB at corrosion and cathodic potential with an improved Devanathan-Stachurski's electrolytic cell.
Abstract: It was found that the corrosion rate of steel in the sea mud with sulfate-reducing bacteria (SRB) could be as high as 10 times of that in the sea mud without SRB. And the hydrogen permeation reaction would occur when metals were corroded. So it is necessary to investigate the effect of living SRB on hydrogen permeation in the sea mud. Cathodic potential was often added to metals in order to protect them. But hydrogen permeation could be affected by the cathodic potential. So it is also necessary to study the effect of cathodic potential on hydrogen permeation. In this paper, the hydrogen permeation actions of APT X56 steel in the sea mud with and without SRB at corrosion and cathodic potential were studied with an improved Devanathan-Stachurski's electrolytic cell. Experimental results showed that during the growth of SRB, the current density curve of hydrogen permeation was accordant with the growth curve of SRB. But the hydrogen permeation current density of APT X56 steel hardly changed in the sterilized sea mud. Compared with the hydrogen permeation current density of APT X56 steel in the sterilized sea mud, the hydrogen permeation of APT X56 steel in the sea mud could be accelerated by living SRB. Experimental results also showed that the hydrogen permeation current density increased rapidly when the cathodic potential was added to the three-electrode system of the cathodic cell, and then the hydrogen permeation current density could obtain a stable value slowly. So the cathodic potential added to the cathodic cell could accelerate hydrogen permeation.

17 citations

Journal ArticleDOI
TL;DR: KV7.1 voltage‐gated potassium channels are expressed in vascular smooth muscle cells (VSMC) of diverse arteries, including mesenteric arteries and stimulation of these channels has been suggested to evoke profound relaxation in various vascular beds of rats.
Abstract: Background and Purpose: KV 7.1 voltage-gated potassium channels are expressed in vascular smooth muscle cells (VSMC) of diverse arteries, including mesenteric arteries. Based on pharmacological evidence using R-L3 (KV 7.1 channel opener), HMR1556, chromanol 293B (KV 7.1 channel blockers), stimulation of these channels has been suggested to evoke profound relaxation in various vascular beds of rats. However, the specificity of these drugs in vivo is uncertain. Experimental Approach: We used Kcnq1(-/-) mice and pharmacological tools to determine whether KV 7.1 channels play a role in the regulation of arterial tone. Key Results: R-L3 produced similar concentration-dependent relaxations (EC50 ~ 1.4 {mu}M) of arteries from wild-type (Kcnq1(+/+) ) and Kcnq1(-/-) mice, pre-contracted with either phenylephrine or 60 mM KCl. This relaxation was not affected by 10 {mu}M chromanol 293B, 10 {mu}M HMR1556 or 30 {mu}M XE991 (pan-KV 7 channel blocker). The anti-contractile effects of the perivascular adipose tissue (PVAT) were normal in Kcnq1(-/-) arteries. Chromanol 293B and HMR1556 did not affect the anti-contractile effects of (PVAT). Isolated VSMCs from Kcnq1(-/-) mice exhibited normal peak KV currents. The KV 7.2-5 channel opener retigabine caused similar relaxations in Kcnq1(-/-) and wild-type vessels. Conclusion and Implications: We conclude that KV 7.1 channels were apparently not involved in the control of arterial tone by α1 -adrenoceptor agonists and PVAT. In addition, R-L3 is an inappropriate pharmacological tool for studying the function of native vascular KV 7.1 channels in mice.

17 citations

Journal ArticleDOI
TL;DR: In this article, a laser beam with T-joint was used to weld a stainless steel 316L to obtain the maximum deformation (2.67 mm) and the maximum value of the longitudinal compressive stress ( 306 MPa) for the whole sample.
Abstract: Austenitic stainless steel 316L is welded by laser beam with T-joint in this paper. Microstructures of fusion zone consist of a large amount of austenite and a small amount of ferrite; heat-affected zone (HAZ) width is about 10 μm. The fine-equiaxed dendrites existing as network morphology locate at the center of fusion zone, and columnar structures are near HAZ. Microhardness at the top of the cross-section of welded joints is higher than that at the bottom, and the hardness of the second pass is higher than that of the first pass. The numerical result of maximum deformation (2.67 mm) keeps a good line with that of the experiment result (2.52 mm). The maximum value of the longitudinal compressive stress is 306 MPa, while the residual stress of the first pass is slightly released during the second pass welding process. The transverse residual stress along line 1 always presents a compressive state. At the 3.5 mm position far from the bead center, a large fluctuation of angular deformation and longitudinal residual stress are induced by the high-temperature gradient. Maximum values of angular deformation and equivalent residual stress for the whole sample are 1.37 mm and 452.3 MPa, and these both locate at the end-start zone of the welding path.

17 citations

Journal ArticleDOI
TL;DR: It is suggested that XBP1S protected MCs from HG-induced apoptosis and necrosis, and CHOP participates in X BP1S-regulated necrosis but not apoptosis.

17 citations

Journal ArticleDOI
TL;DR: It is demonstrated that TRPC5 in endothelial cells contributes to EDC by stimulating the production of COX‐2‐linked prostanoids.

17 citations


Cited by
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08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

01 May 1993
TL;DR: Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems.
Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

29,323 citations

28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

18,940 citations