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Yu Huang

Bio: Yu Huang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Materials science. The author has an hindex of 136, co-authored 1492 publications receiving 89209 citations. Previous affiliations of Yu Huang include The Chinese University of Hong Kong & Samsung.


Papers
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TL;DR: It was concluded that both soybean and kudzu phytoestrogens could modify favorably lipoprotein profiles in ovariectomized and castrated hamsters.
Abstract: The present study compared the hypolipidemic activity of kudzu phytoestrogens with that of soybean phytoestrogen in estrogen- and androgen-deficient hamsters. In the first experiment, ovariectomized hamsters (n = 37) were randomly divided into four groups (n = 9−10 each group). The first group was the control group, whereas the second group had the time-releasing estradiol-17β subcutaneous (pellet) implants as a positive control. The third and fourth groups were orally administered soybean or kudzu phytoestrogen extracts (30 mg/kg of body weight) per day. In the second experiments, the first group of male hamsters (n = 9) received a sham operation, whereas the other three groups of male hamsters (n = 9 each) were castrated. The castrated control group received orally distilled water, whereas the second and third castrated groups were orally given 30 mg/kg soybean or kudzu phytoestrogen extracts. The results for the first experiment showed that the ovariectomized hamsters orally given soybean and kudzu phy...

17 citations

Proceedings ArticleDOI
24 Jun 2002
TL;DR: A segmentation-based method of object tracking using image warping and Kalman filtering based on a second order kinematic model to estimate dominant motion of the object region is proposed.
Abstract: We propose a segmentation-based method of object tracking using image warping and Kalman filtering. The object region is defined to include a group of patches, which are obtained by a watershed algorithm. In a robust M-estimator framework, we estimate dominant motion of the object region. A linear Kalman filter is employed to predict the estimated affine motion parameters based on a second order kinematic model. Image (affine) warping is performed to predict the object region in the next frame. The warping error of each watershed segment (patch) and its rate of overlapping with the predicted region are utilized for classification of watershed segments near the object border. Applications of head and hand tracking using this method demonstrate its performance.

17 citations

Journal ArticleDOI
TL;DR: It was concluded that plasma TG-lowering activity of dietary PMF was mediated by modulating genes involved in lipid metabolism in hamsters, and polymethoxylated flavones may be developed as a nutraceutical to prevent hyperlipidemia and obesity.
Abstract: The present study investigated the underlying mechanism by which citrus polymethoxylated flavones (PMF) reduced plasma triacylglycerols (TG) in hamsters. Four groups of male hamsters were given a non-cholesterol diet (NCD), a high cholesterol diet (HCD), a high cholesterol diet with supplementation of 0.5% PMF (L-PMF), and a high cholesterol diet with supplementation of 1.0% PMF (H-PMF), respectively, for 8 weeks. Results showed PMF could lower plasma TG by 32–46%, but it had no effect on plasma cholesterol. This was accompanied by down-regulation of mRNA of liver sterol regulatory element binding protein-1c (SREBP1c), fatty acid synthase (FAS), and peroxisome proliferator activated receptor alpha (PPARα) while up-regulation of liver lipoprotein lipase (LPL). In addition, dietary PMF increased cholesterol by 5–15% and total lipids by 34–43% in the liver. PMF supplementation also reduced the body weight gain and the relative weights of white adipose tissue pads by 23–39%, possibly by decreasing the gene expression of FAS and LPL in the epididymal fat pad. It was concluded that plasma TG-lowering activity of dietary PMF was mediated by modulating genes involved in lipid metabolism in hamsters. Practical applications: Hyperlipidemia is one of the risk factors for coronary heart diseases. The present study found that polymethoxylated flavones (PMF) were effective in reducing plasma triacylglycerols and adipose tissue weight. PMF may be developed as a nutraceutical to prevent hyperlipidemia and obesity. Citrus polymethoxylated flavones are able to reduce plasma triacylglycerols via two mechanisms of inhibition of lipogenesis and enhancement of lipid uptake by the liver, most likely mediated by down-regulation of SREBP1c and FAS along with up-regulation of LPL in the liver.

17 citations

Journal ArticleDOI
TL;DR: In this paper, a single wavelength position of the Fe I 5324.179 angstrom spectral line was used to calibrate vector magnetic fields, in order to complement the linear calibration at one wavelength position.
Abstract: The Full-disk vector MagnetoGraph (FMG) instrument will carry out polarization observations at one wavelength position of the Fe I 5324.179 angstrom spectral line. This paper describes how to choose this single wavelength position, the relevant data-processing and the magnetic field calibrations based on the measured polarization signals at one single wavelength position. It is found that solar radial Doppler velocity, which can cause the spectral line to shift, is a disadvantageous factor for the linear calibration at one wavelength position. Observations at two symmetric wavelength positions may significantly reduce the wavelength shift effect (similar to 75%), but simulations show that such polarization signals located at the solar limbs (e.g., beyond the longitude range of +/- 30 degrees) are not free from the effect completely. In future work, we plan to apply machine learning techniques to calibrate vector magnetic fields, or employ full Stokes parameter profile inversion techniques to obtain accurate vector magnetic fields, in order to complement the linear calibration at the single wavelength position.

17 citations


Cited by
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08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

01 May 1993
TL;DR: Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems.
Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

29,323 citations

28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

18,940 citations