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Yu Qiu

Researcher at St. Jude Children's Research Hospital

Publications -  30
Citations -  5974

Yu Qiu is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Autophagy & ATG8. The author has an hindex of 11, co-authored 24 publications receiving 5369 citations. Previous affiliations of Yu Qiu include Chinese Academy of Sciences & University of Science and Technology of China.

Papers
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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay.

Myungjin Kim, +23 more
- 26 Jan 2016 - 
TL;DR: The identified a homozygous missense mutation, changing a conserved amino acid, in ATG5 in two siblings with congenital ataxia, mental retardation, and developmental delay are identified, demonstrating the critical role of autophagy in preventing neurological diseases and maintaining neuronal health.
Journal ArticleDOI

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

Hari B. Kamadurai, +15 more
- 08 Aug 2013 - 
TL;DR: This work reports that the second step of ligation is mediated by a distinct catalytic architecture established by both the HECT E3 and its covalently linked ubiquitin, and shows how HECT-specific ubiquit in interactions driving multiple reactions are repurposed by a major E3 conformational change to promote ligation.
Journal ArticleDOI

Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription

Yu Qiu, +11 more
- 15 Jun 2012 - 
TL;DR: The findings suggest that the combinatorial readout of the H3R2/K14ac by PHD12 might represent an important epigenetic regulatory mechanism that governs transcription and also provide a clue of cross-talk between the MOZ complex and histone H3 modifications.
Journal Article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2459 more
- 01 Jan 2016 -