Y
Yu Shan Zou
Researcher at New York University
Publications - 28
Citations - 4984
Yu Shan Zou is an academic researcher from New York University. The author has contributed to research in topics: Glycation & Tissue factor. The author has an hindex of 23, co-authored 28 publications receiving 4780 citations. Previous affiliations of Yu Shan Zou include Columbia University & Columbia University Medical Center.
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Journal ArticleDOI
Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins.
Shi Du Yan,Ann Marie Schmidt,G. M. Anderson,Jinghua Zhang,J Brett,Yu Shan Zou,David J. Pinsky,David M. Stern +7 more
TL;DR: Data indicate that interaction of AGEs with cellular targets, such as ECs, leads to oxidant stress resulting in changes in gene expression and other cellular properties, potentially contributing to the development of vascular lesions.
Journal Article
Survey of the Distribution of a Newly Characterized Receptor for Advanced Glycation End Products in Tissues
Jerold Brett,Ann Marie Schmidt,Shi Du Yan,Yu Shan Zou,Elliott Weidman,David J. Pinsky,Roman Nowygrod,Michael Neeper,Craig Przysiecki,Alan Shaw,Antonio Migheli,David M. Stern +11 more
TL;DR: The results indicate that RAGE is present in multiple tissues and suggest the potential relevance of AGE-RAGE interactions for modulating properties of the vasculature as well as neural and cardiac function, prominent areas of involvement in diabetes and in the normal aging process.
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Glycated tau protein in alzheimer disease : a mechanism for induction of oxidant stress
Shi Du Yan,Xiao-Tao Chen,Ann Marie Schmidt,J Brett,Gabriel C. Godman,Yu Shan Zou,Clay W Scott,C Caputo,T Frappier,Marie-Louise Smith +9 more
TL;DR: It is proposed that in Alzheimer disease, AGEs in paired helical filament tau can induce oxidant stress, thereby promoting neuronal dysfunction, and being ideal substrates for nonenzymatic glycation.
Journal ArticleDOI
Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress
Shi Fang Yan,Tomoyuki Fujita,Jiesheng Lu,Kenji Okada,Yu Shan Zou,Nigel Mackman,David J. Pinsky,David M. Stern +7 more
TL;DR: A central and unifying role is defined for Egr-1 activation in the pathogenesis of ischemic tissue damage as a master switch activated by ischemia to trigger expression of pivotal regulators of inflammation, coagulation and vascular hyperpermeability.
Journal ArticleDOI
Receptor for Advanced-Glycation End Products Key Modulator of Myocardial Ischemic Injury
Loredana G. Bucciarelli,Michiyo Kaneko,Radha Ananthakrishnan,Evis Harja,Larisse K. Lee,Yuying C. Hwang,Shulamit Lerner,Soliman Bakr,Qing Li,Yan Lu,Fei Song,Wu Qu,Teodoro Gomez,Yu Shan Zou,Shi Fang Yan,Ann Marie Schmidt,Ravichandran Ramasamy +16 more
TL;DR: The findings demonstrate novel and key roles for RAGE in I/R injury in the heart and demonstrate that the interaction of RAGE with advanced-glycation end products affects myocardial energy metabolism and function during I-R.