Y
Yu Zhou
Researcher at University of Hong Kong
Publications - 3
Citations - 104
Yu Zhou is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Drug discovery & Membrane protein. The author has an hindex of 2, co-authored 3 publications receiving 32 citations.
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Journal ArticleDOI
Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells.
Yiran Huang,Ling Meng,Qigui Nie,Yu Zhou,Langdong Chen,Shilian Yang,Yi Man Eva Fung,Xiao-Meng Li,Cen Huang,Yan Cao,Yizhou Li,Xiaoyu Li +11 more
TL;DR: In this paper, a method that can specifically label membrane proteins with a DNA tag, and thereby enable target-specific DEL selections against endogenous membrane proteins on live cells without overexpression or any other genetic manipulation.
Journal ArticleDOI
Selection of DNA-Encoded Dynamic Chemical Libraries for Direct Inhibitor Discovery
Yuqing Deng,Jianzhao Peng,Jianzhao Peng,Feng Xiong,Yinan Song,Yu Zhou,Jianfu Zhang,Fong Sang Lam,Chao Xie,Wenyin Shen,Yiran Huang,Ling Meng,Xiaoyu Li +12 more
TL;DR: An anchor-directed DEDL approach is reported that can identify full ligand structures from large-scale D EDLs and is able to convert unbiased libraries to focused ones targeting specific protein classes.
Journal ArticleDOI
Identification of isoform/domain-selective fragments from the selection of DNA-encoded dynamic library.
TL;DR: In this article, a 10,000-member DNA-encoded dynamic combinatorial library (DCL) was selected against sirtuin-1, 2, and 5 domains of bromodomain 4 (BRD4), respectively.