Yuanhan Tang

Bio: Yuanhan Tang is an academic researcher from Ludong University. The author has contributed to research in topics: Self-healing hydrogels & Chemistry. The author has an hindex of 1, co-authored 3 publications receiving 3 citations.

Peptide Hydrogel with Antibacterial Performance Induced by Rare Earth Metal Ions.

Abstract: Metal ion-induced peptide assembly is an interesting field. As compared to traditional antibacterial Ag+, rare earth metal ions possess the advantage of antibacterial performance with photostability and low toxicity. Herein, a new peptide Fmoc-FFWDD-OH was designed and synthesized, which could form a stable hydrogel induced by rare earth metal ions, including Tb3+, Eu3+, and La3+. The mechanical properties were characterized by rheological measurements, and they exhibited elasticity-dominating properties. Transmission electron microscopy (TEM) images showed a large number of nanoscale fiber structures formed in the hydrogel. Circular dichroism (CD) spectra, Fourier transform infrared (FT-IR) spectra, ThT assays, and X-ray diffraction (XRD) pattern illustrated the formation mechanism of the fiber structure. The rare earth ion-induced peptide hydrogel was proved to possess good antibacterial performance on Escherichia coli (E. coli) with excellent biocompatibility. The introduction of rare earth metal ions may have some potential applications in the biological antibacterial and medical fields.

A review on recent advances in amino acid and peptide-based fluorescence and its potential applications

Abstract: Fluorescence is widely used to detect functional groups and ions, and peptides are used in various fields due to their excellent biological activity. In recent years, research on fluorescent amino acids has intensified, especially with the natural fluorescent amino acids such as tryptophan (Trp), tyrosine (Tyr) and phenylalanine (Phe). They use their respective fluorophores to undergo π–π transition under excitation with light of a particular wavelength, and then release a large number of photons, which produce fluorescence. Thus, they are widely used as building units to enhance the fluorescence properties of other molecules. Peptide-based fluorescence technology has expanded the research in the field of biochemistry. Peptide-based fluorescence involving fluorescent amino acids not only retains the biocompatibility of peptides, but also relies on their fluorescent groups to enhance the fluorescent properties of the peptide itself, breaking the original limitations and connecting different fields to complement each other. This review summarizes the luminescence mechanism and fluorescent properties of the natural fluorescent amino acids and focuses on the fluorescence emission of peptides embedded with these fluorescent amino acids or fluorophores. Finally, we summarize the applications of peptide-based fluorescence in sensing drug release, metal ions and biomolecules, and present new challenges and expectations for the future development in this field.

A Review of Recent Advances in Metal Ion Hydrogels: Mechanism, Properties and Their Biological Applications

Abstract: In the past few decades, metal ion hydrogels have made great achievements in various aspects of the biological field. As an ion providing empty orbitals, metal ion was able to...

Principles Of Fluorescence Spectroscopy

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Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Abstract: Three-dimensional (3D) printing is well acknowledged to constitute an important technology in tissue engineering, largely due to the increasing global demand for organ replacement and tissue regeneration. In 3D bioprinting, which is a step ahead of 3D biomaterial printing, the ink employed is impregnated with cells, without compromising ink printability. This allows for immediate scaffold cellularization and generation of complex structures. The use of cell-laden inks or bio-inks provides the opportunity for enhanced cell differentiation for organ fabrication and regeneration. Recognizing the importance of such bio-inks, the current study comprehensively explores the state of the art of the utilization of bio-inks based on natural polymers (biopolymers), such as cellulose, agarose, alginate, decellularized matrix, in 3D bioprinting. Discussions regarding progress in bioprinting, techniques and approaches employed in the bioprinting of natural polymers, and limitations and prospects concerning future trends in human-scale tissue and organ fabrication are also presented.

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Abstract: Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced and solved. Hydrogels have been proposed as excellent candidates for these applications, as they have promising properties for the mentioned applications, including biocompatibility, biodegradability, great absorption capacity and tunable mechanical properties. However, depending on the material or the manufacturing method, the resulting hydrogel may not be up to the specific task for which it is designed, thus there are different approaches proposed to enhance hydrogel performance for the requirements of the application in question. The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popular hydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogels. In addition, the secondary objective of this review was to briefly discuss other novel applications of hydrogels that have been proposed in the past few years which have drawn a lot of attention.