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Yuchen Gao
Researcher at Stanford University
Publications - 19
Citations - 935
Yuchen Gao is an academic researcher from Stanford University. The author has contributed to research in topics: CRISPR & Medicine. The author has an hindex of 6, co-authored 11 publications receiving 520 citations.
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Complex transcriptional modulation with orthogonal and inducible dCas9 regulators
TL;DR: This work provides a robust CRISPR–dCas9-based platform for enacting complex transcription programs that is suitable for large-scale transcriptome engineering and devised AND, OR, NAND, and NOR dCas9 logic operators and a diametric regulator that activates gene expression with one inducer and represses with another.
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CRISPR technologies for precise epigenome editing
TL;DR: A review of currently achievable epigenetic manipulations along with corresponding applications can be found in this paper, where the state of the art of epigenetic manipulation can be seen as a set of tools for understanding and controlling biological function.
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CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization
Haifeng Wang,Xiaoshu Xu,Cindy M. Nguyen,Yanxia Liu,Yuchen Gao,Xueqiu Lin,Timothy Daley,Nathan H. Kipniss,Marie La Russa,Lei S. Qi +9 more
TL;DR: A versatile CRISPR-genome organization system that can efficiently control the spatial positioning of genomic loci relative to specific nuclear compartments, including the nuclear periphery, Cajal bodies, and promyelocytic leukemia (PML) bodies is developed.
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Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells
Muneaki Nakamura,Prashanth Srinivasan,Michael Chavez,Matthew A. Carter,Antonia A. Dominguez,Marie La Russa,Matthew B. Lau,Timothy R. Abbott,Xiaoshu Xu,Dehua Zhao,Yuchen Gao,Nathan H. Kipniss,Christina D. Smolke,Joseph Bondy-Denomy,Lei S. Qi +14 more
TL;DR: It is demonstrated that cells pre-engineered with anti-CRISPR molecules become resistant to gene editing, thus providing a means to generate “write-protected” cells that prevent future gene editing.
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A Single-Chain Photoswitchable CRISPR-Cas9 Architecture for Light-Inducible Gene Editing and Transcription
TL;DR: This design successfully controlled different species and functional variants of Cas9, mediated transcriptional activation more robustly than previous optogenetic methods, and enabled light-induced transcription of one gene and editing of another in the same cells.