Yuchuan Wang

TL;DR: A cell-permeable small molecule (JQ1) that binds competitively to acetyl-lysine recognition motifs, or bromodomains is reported, establishing proof-of-concept for targeting protein–protein interactions of epigenetic ‘readers’, and providing a versatile chemical scaffold for the development of chemical probes more broadly throughout the b romodomain family.

TL;DR: It is demonstrated that concomitant loss of either p53 or Lkb1, two clinically relevant tumour suppressors, markedly impaired the response of Kras-mutant cancers to docetaxel monotherapy, highlighting the rationale for synchronous co-clinical trials.

TL;DR: These findings attest to the feasibility of completely destroying advanced, highly glycolytic cancers.

TL;DR: The combination of high spatial resolution, resolution uniformity, sensitivity, and count rate performance, made possible in part by the novel use of phoswich detector modules, confers significant technical advantages over machines with similar geometry but without DOI correction capability.

TL;DR: The results show the feasibility of imaging PSMA-positive prostate cancer using low molecular weight agents, including radiolabeled urea derivatives.