Y
Yue Wan
Researcher at Genome Institute of Singapore
Publications - 37
Citations - 6020
Yue Wan is an academic researcher from Genome Institute of Singapore. The author has contributed to research in topics: RNA & Nucleic acid structure. The author has an hindex of 13, co-authored 36 publications receiving 5202 citations. Previous affiliations of Yue Wan include Howard Hughes Medical Institute & Nanyang Technological University.
Papers
More filters
Journal ArticleDOI
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Miao-Chih Tsai,Ohad Manor,Yue Wan,Nima Mosammaparast,Jordon K. Wang,Fei Lan,Yang Shi,Eran Segal,Howard Y. Chang +8 more
TL;DR: The results suggest that lincRNAs may serve as scaffolds by providing binding surfaces to assemble select histone modification enzymes, thereby specifying the pattern of histone modifications on target genes.
Journal ArticleDOI
Genome-wide measurement of RNA secondary structure in yeast
TL;DR: A novel strategy termed parallel analysis of RNA structure (PARS), which is based on deep sequencing fragments of RNAs that were treated with structure-specific enzymes, is described, thus providing simultaneous in vitro profiling of the secondary structure of thousands of RNA species at single nucleotide resolution.
Journal ArticleDOI
Landscape and variation of RNA secondary structure across the human transcriptome
Yue Wan,Kun Qu,Qiangfeng Cliff Zhang,Ryan A. Flynn,Ohad Manor,Zhengqing Ouyang,Jiajing Zhang,Robert C. Spitale,Michael Snyder,Eran Segal,Howard Y. Chang +10 more
TL;DR: The initial landscape and variation of RNA secondary structures (RSSs) in a human family trio (mother, father and their child) is reported, which provides a comprehensive RSS map of human coding and non-coding RNAs.
Journal ArticleDOI
Understanding the transcriptome through RNA structure
TL;DR: With additional advances in method refinement and interpretation, structural views of the transcriptome should help to identify and validate regulatory RNA motifs that are involved in diverse cellular processes and thereby increase understanding of RNA function.
Journal ArticleDOI
In Vivo Mapping of Eukaryotic RNA Interactomes Reveals Principles of Higher-Order Organization and Regulation.
Jong Ghut Ashley Aw,Yang Shen,Andreas Wilm,Miao Sun,Xin Ni Lim,Kum-Loong Boon,Sidika Tapsin,Yun-Shen Chan,Cheng-Peow Tan,Adelene Y. L. Sim,Tong Zhang,Teodorus Theo Susanto,Zhiyan Fu,Niranjan Nagarajan,Yue Wan +14 more
TL;DR: A high-throughput approach, sequencing of psoralen crosslinked, ligated, and selected hybrids (SPLASH), that maps pairwise RNA interactions in vivo with high sensitivity and specificity, genome-wide, highlights the underexplored complexity of RNA interactomes and pave the way to better understanding how RNA organization impacts biology.