Yue Zhong Wu

TL;DR: Older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait, indicating how an appreciation of epigenetics is missing from the understanding of how different phenotypes can be originated from the same genotype.

TL;DR: These results provide evidence that the mechanisms of Sp1/NFkappaB/HDAC/miR-29b-dependent KIT overexpression contribute to leukemia growth and can be successfully targeted by pharmacological disruption of the Sp1 /NFkappB/ HDAC complex or synthetic miR- 29b treatment in KIT-driven AML.

TL;DR: This work developed a mouse model of T/natural killer acute lymphoblastic leukemia that is always preceded by polyclonal lymphocyte expansion to determine how aberrant promoter DNA methylation and consequent gene silencing might be contributing to leukemic transformation.

TL;DR: Current methods of hESC propagation can rapidly programme stable and unpredictable epigenetic changes in the stem cell genome, which highlights the need for novel screening strategies and standardization of procedures for the derivation and culture of h ESC lines that minimize culture-induced instability.

TL;DR: One novel amplicon is identified on chromosome 11q22, in addition to previously reported amplicons that include oncogenes MYCC, MYCL1 and previously identified amplification of chromosomal regions 6q21 and 3q26-27, which has been reported in other types of cancer.