Yuen-Joyce Liu

TL;DR: It is shown that Nod2 plays an essential role in controlling commensal bacterial flora in the intestine by regulating each other through a feedback mechanism, and Dysfunction of Nod1 results in a break-down of this homeostasis.

TL;DR: NLRC5 is identified as a transcriptional regulator, orchestrating the concerted expression of critical components in the MHC class I pathway, and induced the expression of β2-microglobulin, transporter associated with antigen processing, and large multifunctional protease, which are essential for M HC class I antigen presentation.

TL;DR: Nod2-deficient mice inoculated with Helicobacter hepaticus developed granulomatous inflammation of the ileum, characterized by an increased expression of Th1-related genes and inflammatory cytokines, which may provide insight into Nod2 function relevant to inflammation of ileal Crohn’s disease.

TL;DR: It is shown that NLRC5-mediated MHC class I gene induction requires the W/S and X1, X2 cis-regulatory elements and can cooperate with ATF1 and the transcriptional coactivators CBP/p300 and general control nonderepressible 5, which display histone acetyltransferase activity.

TL;DR: The structural modifications of MDP and its derivatives have been extensively studied in an attempt to increase adjuvant activity and boost the immune response effectively for clinical use in the treatment of cancer and other diseases.