Y
Yufen Goh
Researcher at National University of Singapore
Publications - 10
Citations - 1429
Yufen Goh is an academic researcher from National University of Singapore. The author has contributed to research in topics: Chromatin & ChIA-PET. The author has an hindex of 5, co-authored 8 publications receiving 1249 citations. Previous affiliations of Yufen Goh include Agency for Science, Technology and Research & Genome Institute of Singapore.
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Journal ArticleDOI
Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation.
Guoliang Li,Xiaoan Ruan,Raymond K. Auerbach,Kuljeet Singh Sandhu,Meizhen Zheng,Ping Wang,Huay Mei Poh,Yufen Goh,Joanne Lim,Jingyao Zhang,Hui Shan Sim,Su Qin Peh,Fabianus Hendriyan Mulawadi,Chin Thing Ong,Yuriy L. Orlov,Shuzhen Hong,Zhizhuo Zhang,Steve Landt,Debasish Raha,Ghia Euskirchen,Chia-Lin Wei,Weihong Ge,Huaien Wang,Carrie A. Davis,Katherine I. Fisher-Aylor,Ali Mortazavi,Mark Gerstein,Thomas R. Gingeras,Barbara J. Wold,Yi Sun,Melissa J. Fullwood,Edwin Cheung,Edwin Cheung,Edison T. Liu,Wing-Kin Sung,Wing-Kin Sung,Michael Snyder,Yijun Ruan,Yijun Ruan +38 more
TL;DR: In conclusion, this study provides insights into transcription regulation by three-dimensional chromatin interactions for both housekeeping and cell-specific genes in human cells through widespread promoter-centered intragenic, extragenics, and intergenic interactions.
Journal ArticleDOI
ChIA-PET analysis of transcriptional chromatin interactions
Jingyao Zhang,Huay Mei Poh,Su Qin Peh,Yee Yen Sia,Guoliang Li,Fabianus Hendriyan Mulawadi,Yufen Goh,Melissa J. Fullwood,Wing-Kin Sung,Xiaoan Ruan,Yijun Ruan +10 more
TL;DR: Detailed procedures of the ChIA-PET methodology are described, unraveling transcription-associated chromatin contacts in a model human cell line, providing a global and unbiased interrogation of higher-order chromatin structures associated with specific protein factors.
Journal ArticleDOI
Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions
Fan Cao,Yiwen Fang,Hong Kee Tan,Yufen Goh,Jocelyn Yeen Hui Choy,Bryan Thean Howe Koh,Jiong Hao Tan,Nicolas Bertin,Aroul Ramadass,Ewan Hunter,Jayne Green,Matthew Salter,Alexandre Akoulitchev,Wilson Wang,Wee Joo Chng,Wee Joo Chng,Daniel G. Tenen,Melissa J. Fullwood +17 more
TL;DR: Results reveal a new layer of complexity in gene regulation by super-enhancers and broad H3K4me3 domains and show high association with cancer-associated genes including tumor suppressor genes.
Journal ArticleDOI
NanoVar: accurate characterization of patients' genomic structural variants using low-depth nanopore sequencing.
Cheng Yong Tham,Roberto Tirado-Magallanes,Yufen Goh,Melissa J. Fullwood,Melissa J. Fullwood,Bryan T. H. Koh,Wilson Wang,Chin Hin Ng,Wee Joo Chng,Alexandre H. Thiery,Daniel G. Tenen,Daniel G. Tenen,Touati Benoukraf,Touati Benoukraf +13 more
TL;DR: NanoVar, an optimized structural variant caller utilizing low-depth whole-genome sequencing data generated by Oxford Nanopore Technologies, is presented and exhibits higher structural variant calling accuracy when benchmarked against current tools using low- depth simulated datasets.
Journal ArticleDOI
Chromatin Interaction Analysis with Paired-End Tag Sequencing (ChIA-PET) for mapping chromatin interactions and understanding transcription regulation.
Yufen Goh,Melissa J. Fullwood,Melissa J. Fullwood,Huay Mei Poh,Su Qin Peh,Chin Thing Ong,Jingyao Zhang,Xiaoan Ruan,Yijun Ruan,Yijun Ruan +9 more
TL;DR: This work has produced a video to demonstrate critical aspects of the ChIA-PET protocol, especially the preparation of ChIP as the quality of Chip plays a major role in the outcome of a Chia-PET library.