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Yuichi Kaji
Researcher at University of Tsukuba
Publications - 120
Citations - 4310
Yuichi Kaji is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Cornea & Glycation. The author has an hindex of 34, co-authored 115 publications receiving 4052 citations. Previous affiliations of Yuichi Kaji include University of Tokyo & Kyoto University.
Papers
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Journal ArticleDOI
VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization.
Susumu Ishida,Tomohiko Usui,Tomohiko Usui,Kenji Yamashiro,Kenji Yamashiro,Yuichi Kaji,Yuichi Kaji,Shiro Amano,Yuichiro Ogura,Tetsuo Hida,Yoshihisa Oguchi,Jayakrishna Ambati,Joan W. Miller,Evangelos S. Gragoudas,Yin-Shan Ng,Patricia A. D'Amore,David T. Shima,Anthony P. Adamis +17 more
TL;DR: During pathological neovascularization, VEGF164 selectively induces inflammation and cellular immunity, which provide positive and negative angiogenic regulation, respectively, and new therapeutic approaches for selectively targeting pathological, but not physiological, retinal neov vascularization are outlined.
Journal ArticleDOI
VEGF164 is proinflammatory in the diabetic retina.
Susumu Ishida,Tomohiko Usui,Tomohiko Usui,Kenji Yamashiro,Kenji Yamashiro,Yuichi Kaji,Yuichi Kaji,Ednan Ahmed,Karen G. Carrasquillo,Shiro Amano,Tetsuo Hida,Yoshihisa Oguchi,Anthony P. Adamis +12 more
TL;DR: The inhibition of diabetic retinal leukostasis and BRB breakdown with EYE001 in early and established diabetes indicates that VEGF(164) is an important isoform in the pathogenesis of early diabetic retinopathy.
Journal ArticleDOI
Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease.
Susumu Ishida,Kenji Yamashiro,Kenji Yamashiro,Tomohiko Usui,Tomohiko Usui,Yuichi Kaji,Yuichi Kaji,Yuichiro Ogura,Tetsuo Hida,Yoshihito Honda,Yoshihisa Oguchi,Anthony P. Adamis +11 more
TL;DR: It is shown that leukocytes prune the retinal vasculature during normal development and obliterate it in disease, and these pathways may prove useful in the treatment of retinal ischemia, a leading cause of vision loss and blindness.
Journal ArticleDOI
Absence of ACAT-1 Attenuates Atherosclerosis but Causes Dry Eye and Cutaneous Xanthomatosis in Mice with Congenital Hyperlipidemia
Hiroaki Yagyu,Tetsuya Kitamine,Jun-ichi Osuga,Ryu-ichi Tozawa,Zhong Chen,Yuichi Kaji,Teruaki Oka,Stéphane Perrey,Yoshiaki Tamura,Ken Ohashi,Hiroaki Okazaki,Naoya Yahagi,Futoshi Shionoiri,Yoko Iizuka,Kenji Harada,Hitoshi Shimano,Hidetoshi Yamashita,Takanari Gotoda,Nobuhiro Yamada,Shun Ishibashi +19 more
TL;DR: The results indicate that the local inhibition of ACAT activity in tissue macrophages is protective against cholesteryl ester accumulation but causes cutaneous xanthomatosis in mice that lack apo E or LDLR.
Journal Article
Advanced glycation end products in diabetic corneas.
Yuichi Kaji,Tomohiko Usui,Tetsuro Oshika,Masao Matsubara,Hidetoshi Yamashita,Makoto Araie,Toshinori Murata,Tatsuro Ishibashi,Ryoji Nagai,Seikoh Horiuchi,Shiro Amano +10 more
TL;DR: The presence of amninoguanidine in the incubation mixture during glycation inhibited CML formation and promoted the adhesion and spreading of corneal epithelial cells in a dose-dependent manner.