Yuji Nashimoto

TL;DR: A novel multicellular spheroid culture system that facilitates the easy preparation and culture of aSpheroid microarray for the long-term monitoring of cellular activity and functioning as a useful drug-screening device for cancer and liver cells is described.

TL;DR: A tumor-on-a-chip platform that enables the evaluation of tumor activities with intraluminal flow in an engineered tumor vascular network and the results demonstrate the importance of flow in a vascular network for the evaluationof tumor activities in a drug screening platform are presented.

TL;DR: It is demonstrated that the vascular network could administer biological substances to the interior of the spheroid, and the perfusable vasculature model opens up new possibilities for a long-term tissue culture in vitro.

TL;DR: This study shows that SICM imaging can be utilized for the analysis of mRNA localization in single cells and fully automated the pipet movement in the XYZ-directions during the puncturing processes, making it applicable as a high-throughput system for collecting cytosol and analyzing mRNA localization.

TL;DR: This method realizes the analysis of mRNA at the single cell level and the identification of the cell types on the basis of the relative gene expression profiles.