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Author

Yujing Wang

Other affiliations: Maastricht University
Bio: Yujing Wang is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Drug delivery & Life expectancy. The author has an hindex of 6, co-authored 12 publications receiving 130 citations. Previous affiliations of Yujing Wang include Maastricht University.

Papers
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Journal ArticleDOI
TL;DR: Microneedle‐based transdermal and ocular drug delivery systems have the potential to greatly impact not only patient benefits, but also industry, and through diligence, innovation and collaboration, their true potential will begin to be realised within the next 3–5 years.

47 citations

Journal ArticleDOI
TL;DR: The challenges and opportunities of posterior segment drug delivery via the periocular route are highlighted, and the importance of understanding complex barrier functions so as to continue to develop innovative drug-delivery systems is envisaged.
Abstract: Drug delivery to the posterior segment via the periocular route is a promising route for delivery of a range of formulations. In this review, we have highlighted the challenges and opportunities of posterior segment drug delivery via the periocular route. Consequently, we have discussed different types of periocular routes, physiological barriers that limit effective drug delivery, practical challenges regarding patient compliance and acceptability and recent advances in developing innovative strategies to enhance periocular drug delivery. We conclude with a perspective on how we envisage the importance of understanding complex barrier functions so as to continue to develop innovative drug-delivery systems.

34 citations

Journal ArticleDOI
TL;DR: In this article, a model protein, ovalbumin (OVA)-encapsulated PLGA NPs were prepared and optimized using a water-in-oil-inwater (W/O/W) double emulsion method.

27 citations

Journal ArticleDOI
TL;DR: This work provides a useful approach for the fabrication of drug-eluting beads used in transarterial chemoembolization by providing in vitro cytotoxicity experiments and classical matrigel endothelial tube assay certificated the maintaining bioactivity of cisplatin and sorafenib tosylate released from the microspheres, respectively.
Abstract: Biodegradable poly(D,L-lactic acid) drug-eluting microspheres containing anti-tumor drugs, cisplatin, and sorafenib tosylate have been prepared by the emulsion solvent evaporation method with diameter between 200 and 400 μm. Scanning electron microscopy showed that cisplatin microspheres had smooth surfaces, while sorafenib tosylate microspheres and cisplatin + sorafenib tosylate microspheres were porous at the surface and the pits of the latter were larger than those of the former. Notably, cisplatin + sorafenib tosylate microspheres had a fast drug release rate compared with microspheres containing one drug alone. In vitro cytotoxicity experiments and classical matrigel endothelial tube assay certificated the maintaining bioactivity of cisplatin and sorafenib tosylate released from the microspheres, respectively. This work provides a useful approach for the fabrication of drug-eluting beads used in transarterial chemoembolization.

23 citations

Journal ArticleDOI
TL;DR: This study demonstrates the applicability of biodegradable poly(D,L-lactic acid) microspheres loaded with cisplatin and sorafenib tosylate for local drug delivery as well as the potential of thesemicrospheres for future use in transarterial chemoembolization.

22 citations


Cited by
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Journal Article
TL;DR: Degradable biomaterials have been investigated for biomedical applications with novel materials constantly being developed to meet new challenges as mentioned in this paper, and a review summarizes the most recent advances in the field over the past four years, specifically highlighting new and interesting discoveries in tissue engineering and drug delivery applications.
Abstract: Utilization of polymers as biomaterials has greatly impacted the advancement of modern medicine. Specifically, polymeric biomaterials that are biodegradable provide the significant advantage of being able to be broken down and removed after they have served their function. Applications are wide ranging with degradable polymers being used clinically as surgical sutures and implants. To fit functional demand, materials with desired physical, chemical, biological, biomechanical, and degradation properties must be selected. Fortunately, a wide range of natural and synthetic degradable polymers has been investigated for biomedical applications with novel materials constantly being developed to meet new challenges. This review summarizes the most recent advances in the field over the past 4 years, specifically highlighting new and interesting discoveries in tissue engineering and drug delivery applications.

275 citations

Journal ArticleDOI
12 Dec 2018-Polymers
TL;DR: An overview of classification of these drug delivery devices; the mechanism of drug release; the materials used for manufacture; the various methods of manufacture; and examples of clinical applications of implantable drug Delivery devices are given.
Abstract: The oral route is a popular and convenient means of drug delivery. However, despite its advantages, it also has challenges. Many drugs are not suitable for oral delivery due to: first pass metabolism; less than ideal properties; and side-effects of treatment. Additionally, oral delivery relies heavily on patient compliance. Implantable drug delivery devices are an alternative system that can achieve effective delivery with lower drug concentrations, and as a result, minimise side-effects whilst increasing patient compliance. This article gives an overview of classification of these drug delivery devices; the mechanism of drug release; the materials used for manufacture; the various methods of manufacture; and examples of clinical applications of implantable drug delivery devices.

211 citations

Journal ArticleDOI
TL;DR: In this review, a great effort has been made to summarize the advance of microneedles including their materials and latest fabrication method, such as three-dimensional printing (3DP).

203 citations

Journal ArticleDOI
TL;DR: This overview on skin delivery considers the evolution of the principles of percutaneous ab-sorption and skin products from ancient times to today and the development of technologies to effectively and quantitatively deliver solutes across this barrier to specific target sites in the skin and beyond.
Abstract: This overview on skin delivery considers the evolution of the principles of percutaneous absorption and skin products from ancient times to today. Over the ages, it has been recognised that products may be applied to the skin for either local or systemic effects. As our understanding of the anatomy and physiology of the skin has improved, this has facilitated the development of technologies to effectively and quantitatively deliver solutes across this barrier to specific target sites in the skin and beyond. We focus on these technologies and their role in skin delivery today and in the future.

159 citations

Journal ArticleDOI
TL;DR: The least invasive routes for ocular drug administration are topical (e.g. eyedrops) and systemic formulations as discussed by the authors, however, topical drugs often display limited bioavailability due to many physical and biochemical barriers including the pre-corneal tear film, the structure and biophysiologic properties of the cornea, the limited volume that can be accommodated by the cul-desac, the lacrimal drainage system and reflex tearing.
Abstract: The eye is a highly specialised organ that is subject to a huge range of pathology. Both local and systemic disease may affect different anatomical regions of the eye. The least invasive routes for ocular drug administration are topical (e.g. eyedrops) and systemic (e.g. tablets) formulations. Barriers that subserve as protection against pathogen entry also restrict drug permeation. Topically administered drugs often display limited bioavailability due to many physical and biochemical barriers including the pre-corneal tear film, the structure and biophysiologic properties of the cornea, the limited volume that can be accommodated by the cul-de-sac, the lacrimal drainage system and reflex tearing. The tissue layers of cornea and conjunctiva are further key restrictors to drug delivery. Using carriers that enhance viscosity or bind to the ocular surface increase bioavailability. Matching the pH and polarity of drug molecules to the tissue layers allows greater penetration. Drug delivery to the posterior segment is a greater challenge and currently the standard route is via intravitreal (IVT) injection, notwithstanding the risks of endophthalmitis and retinal detachment with frequent injections. Intraocular implants that allow sustained drug release are at different stages of development. Novel exciting therapeutic approaches include methods for promoting transscleral delivery, sustained release devices, nanotechnology and gene therapy.

132 citations