Yuko Futahashi

TL;DR: It is hypothesized that CXCR4 distributes to the cell surface as a multimer, in order to effectively sense, with increased avidity, the chemotaxis‐inducing ligand in the microenvironment, and this is the first report providing direct experimental evidence for the higher‐order multimerization of CX CR4 in vivo.

TL;DR: Analysis of the role of the CXCR4 cytoplasmic tail in steady‐state internalization using the NP2 cell line demonstrates that ligand‐dependent and ‐independent internalization is genetically separable and that, between amino acids 336 and 342, there is a negative regulatory element for ligand-promoted internalization.

TL;DR: Data suggest that NACME derivatives may be potent lead compounds for development of a novel class of antiretroviral drugs.

TL;DR: This study replaced the myristoylation signal of MA with a well-studied phosphatidylinositol 4,5-biphosphate-binding plasma membrane (PM) targeting motif, the phospholipase C-δ1 pleckstrin homology (PH) domain, and demonstrated infectious pseudovirion production without myristoyslated Pr55Gag.

TL;DR: Data indicate that HEXIM1 is a host factor that negatively regulates lentiviral replication specifically, and elucidating the regulatory mechanism of HexIM1 might lead to ways to control lentivirus replication.