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Yuliang Zhao

Bio: Yuliang Zhao is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Photothermal therapy. The author has an hindex of 93, co-authored 538 publications receiving 30249 citations. Previous affiliations of Yuliang Zhao include Tokyo Metropolitan University & Houston Methodist Hospital.


Papers
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Journal ArticleDOI
23 May 2011-Small
TL;DR: This article focusses on the cellular uptake, location and translocation, and any biological consequences, such as cytotoxicity, of the most widely studied and used nanoparticles,such as carbon-based nanoparticle, metallic nanoparticles and quantum dots.
Abstract: The interactions of nanoparticles with the soft surfaces of biological systems like cells play key roles in executing their biomedical functions and in toxicity. The discovery or design of new biomedical functions, or the prediction of the toxicological consequences of nanoparticles in vivo, first require knowledge of the interplay processes of the nanoparticles with the target cells. This article focusses on the cellular uptake, location and translocation, and any biological consequences, such as cytotoxicity, of the most widely studied and used nanoparticles, such as carbon-based nanoparticles, metallic nanoparticles, and quantum dots. The relevance of the size and shape, composition, charge, and surface chemistry of the nanoparticles in cells is considered. The intracellular uptake pathways of the nanoparticles and the cellular responses, with potential signaling pathways activated by nanoparticle interactions, are also discussed.

1,000 citations

Journal ArticleDOI
Beatriz Pelaz1, Christoph Alexiou2, Ramon A. Alvarez-Puebla3, Frauke Alves4, Frauke Alves5, Anne M. Andrews6, Sumaira Ashraf1, Lajos P. Balogh, Laura Ballerini7, Alessandra Bestetti8, Cornelia Brendel1, Susanna Bosi9, Mónica Carril10, Warren C. W. Chan11, Chunying Chen, Xiaodong Chen12, Xiaoyuan Chen13, Zhen Cheng14, Daxiang Cui15, Jianzhong Du16, Christian Dullin4, Alberto Escudero17, Alberto Escudero1, Neus Feliu18, Mingyuan Gao, Michael D. George, Yury Gogotsi19, Arnold Grünweller1, Zhongwei Gu20, Naomi J. Halas21, Norbert Hampp1, Roland K. Hartmann1, Mark C. Hersam22, Patrick Hunziker23, Ji Jian24, Xingyu Jiang, Philipp Jungebluth25, Pranav Kadhiresan11, Kazunori Kataoka26, Ali Khademhosseini27, Jindřich Kopeček28, Nicholas A. Kotov29, Harald F. Krug30, Dong Soo Lee31, Claus-Michael Lehr32, Kam W. Leong33, Xing-Jie Liang34, Mei Ling Lim18, Luis M. Liz-Marzán10, Xiaowei Ma34, Paolo Macchiarini35, Huan Meng6, Helmuth Möhwald5, Paul Mulvaney8, Andre E. Nel6, Shuming Nie36, Peter Nordlander21, Teruo Okano, Jose Oliveira, Tai Hyun Park31, Reginald M. Penner37, Maurizio Prato9, Maurizio Prato10, Víctor F. Puntes38, Vincent M. Rotello39, Amila Samarakoon11, Raymond E. Schaak40, Youqing Shen24, Sebastian Sjöqvist18, Andre G. Skirtach41, Andre G. Skirtach5, Mahmoud Soliman1, Molly M. Stevens42, Hsing-Wen Sung43, Ben Zhong Tang44, Rainer Tietze2, Buddhisha Udugama11, J. Scott VanEpps29, Tanja Weil5, Tanja Weil45, Paul S. Weiss6, Itamar Willner46, Yuzhou Wu5, Yuzhou Wu47, Lily Yang, Zhao Yue1, Qian Zhang1, Qiang Zhang48, Xian-En Zhang, Yuliang Zhao, Xin Zhou, Wolfgang J. Parak1 
14 Mar 2017-ACS Nano
TL;DR: An overview of recent developments in nanomedicine is provided and the current challenges and upcoming opportunities for the field are highlighted and translation to the clinic is highlighted.
Abstract: The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic.

926 citations

Journal ArticleDOI
TL;DR: It is successfully revealed that the cationic PDDAC-coated Au NRs with an aspect ratio of 4 possess an ideal combination of both negligible toxicity and high cellular uptake efficiency, showing a great promise as photothermal therapeutic agents.

629 citations

Journal ArticleDOI
TL;DR: Recent investigations into the basis of CNT toxicity carried out by the team and by other laboratories are highlighted, highlighting several important factors that explain the disparities in the experimental results of nanotoxicity, such as impurities, amorphous carbon, surface charge, shape, length, agglomeration, and layer numbers.
Abstract: Because of their unique physical, chemical, electrical, and mechanical properties, carbon nanotubes (CNTs) have attracted a great deal of research interest and have many potential applications. As large-scale production and application of CNTs increases, the general population is more likely to be exposed to CNTs either directly or indirectly, which has prompted considerable attention about human health and safety issues related to CNTs. Although considerable experimental data related to CNT toxicity at the molecular, cellular, and whole animal levels have been published, the results are often conflicting. Therefore, a systematic understanding of CNT toxicity is needed but has not yet been developed. In this Account, we highlight recent investigations into the basis of CNT toxicity carried out by our team and by other laboratories. We focus on several important factors that explain the disparities in the experimental results of nanotoxicity, such as impurities, amorphous carbon, surface charge, shape, length, agglomeration, and layer numbers. The exposure routes, including inhalation, intravenous injection, or dermal or oral exposure, can also influence the in vivo behavior and fate of CNTs. The underlying mechanisms of CNT toxicity include oxidative stress, inflammatory responses, malignant transformation, DNA damage and mutation (errors in chromosome number as well as disruption of the mitotic spindle), the formation of granulomas, and interstitial fibrosis. These findings provide useful insights for de novo design and safe application of carbon nanotubes and their risk assessment to human health. To obtain reproducible and accurate results, researchers must establish standards and reliable detection methods, use standard CNT samples as a reference control, and study the impact of various factors systematically. In addition, researchers need to examine multiple types of CNTs, different cell lines and animal species, multidimensional evaluation methods, and exposure conditions. To make results comparable among different institutions and countries, researchers need to standardize choices in toxicity testing such as that of cell line, animal species, and exposure conditions. The knowledge presented here should lead to a better understanding of the key factors that can influence CNT toxicity so that their unwanted toxicity might be avoided.

617 citations

Journal ArticleDOI
TL;DR: The NIR laser-induced targeted cancer thermo-chemotherapy without using targeting ligands represents a novel targeted anticancer strategy with facile control and practical efficacy.
Abstract: External stimuli, such as ultrasound, magnetic field, and light, can be applied to activate in vivo tumor targeting. Herein, we fabricated polymer encapsulated gold nanorods to couple the photothermal properties of gold nanorods and the thermo- and pH-responsive properties of polymers in a single nanocomposite. The activation mechamism was thus transformed from heat to near-infrared (NIR) laser, which can be more easily controlled. Doxorubicin, a clinical anticancer drug, can be loaded into the nanocomposite through electrostatic interactions with high loading content up to 24%. The nanocomposite’s accumulation in tumor post systematic administration can be significantly enhanced by NIR laser irradiation, providing a prerequisite for their therapeutic application which almost completely inhibited tumor growth and lung metastasis. Since laser can be manipulated very precisely and flexibly, the nanocomposite provides an ideally versatile platform to simultaneously deliver heat and anticancer drugs in a lase...

555 citations


Cited by
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28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

18,940 citations

Journal ArticleDOI
TL;DR: Recent advances in the design of nanoscale stimuli-responsive systems that are able to control drug biodistribution in response to specific stimuli, either exogenous (variations in temperature, magnetic field, ultrasound intensity, light or electric pulses) or endogenous (changes in pH, enzyme concentration or redox gradients).
Abstract: Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible. Implementation of such devices requires the use of biocompatible materials that are susceptible to a specific physical incitement or that, in response to a specific stimulus, undergo a protonation, a hydrolytic cleavage or a (supra)molecular conformational change. In this Review, we discuss recent advances in the design of nanoscale stimuli-responsive systems that are able to control drug biodistribution in response to specific stimuli, either exogenous (variations in temperature, magnetic field, ultrasound intensity, light or electric pulses) or endogenous (changes in pH, enzyme concentration or redox gradients).

4,836 citations